Advanced Prostate Cancer VL

Combination Therapy Jolts 'Exhausted' Immune Cells Awake to Attack Tumors in Patients with Metastatic Castration-Sensitive Prostate Cancer - Jessica Hawley & Aleksandar Obradovic

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Andrea hosts Jessica Hawley and Aleksandar Obradovic to discuss their study, published in Cancer Cell, which explores the effects of combining Anti-PD-1 immunotherapy with Androgen Deprivation Therapy (ADT) in metastatic castration-sensitive prostate cancer. The research, part of the PRIME-CUT Study, used advanced techniques like single-cell RNA sequencing and quantitative immunofluorescence to an...

ENZA-p Trial Shows Promise for Enzalutamide-Lutetium Combination in Prostate Cancer - Louise Emmett

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Alicia Morgans speaks with Louise Emmett about the ENZA-p study, presented at ESMO 2023. This groundbreaking research explores the combination of lutetium and enzalutamide in treating early metastatic castrate-resistant prostate cancer. Patients, previously showing limited response to enzalutamide, were screened with PSMA PET and randomized to receive either enzalutamide alone or combined with lut...

Harnessing Tumor Biology to Improve Outcomes in Advanced Hormone-Sensitive Prostate Cancer - Gerhardt Attard

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Gerhardt Attard discusses advancing the treatment of advanced hormone-sensitive prostate cancer through biological research. Dr. Attard's work focuses on two main areas: analyzing tumor samples from clinical trials to understand the biology driving cancer aggressiveness and identifying new therapeutic targets. He emphasizes the need for prognostic tests to tailor treatments, especially considering...

Novel STEAP1 Targeted BiTE Therapy Demonstrates Early Efficacy in Phase 1 Trial - William Kevin Kelly

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Kevin Kelly discusses a groundbreaking approach to prostate cancer treatment with Alicia Morgans. He presents Xaluritamig (AMG 509) a novel bi-specific antibody targeting the STEAP1 protein, prevalent in prostate cancer cells. This innovative therapy, a form of biTE therapy, is designed to attract T-cells for targeted cytotoxicity. In a phase one trial involving advanced prostate cancer patients w...

Shifting Clinical Trial Design Towards Improving Patient Enrollment - Michael Morris

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Alicia Morgans engages with Michael Morris to discuss the transformation of clinical trial design to improve patient access and applicability of results. Dr. Morris highlights the complexity of current clinical trials, which often involve extensive documentation and stringent eligibility criteria, limiting participation to a narrow patient population and placing a heavy burden on both participants...

AMG 509's Potential in Prostate Cancer Therapy - Michael Morris

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Michael Morris highlights notable prostate cancer trials, focusing on AMG 509, a bispecific antibody targeting STEAP1 and CD3. This promising early-phase study, still determining optimal dosages, shows potential in treating prostate cancer, a field historically resistant to immune therapy. Dr. Morris emphasizes AMG 509's ability to reduce bony and visceral diseases, including liver disease, with m...

Genetic Testing Reveals Treatment Opportunity and Disparity in Advanced Prostate Cancer - Colin Pritchard

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Zach Klaassen engages with Colin Pritchard in a detailed discussion about genomic testing in prostate cancer. They emphasize the importance of genomic testing, particularly in advanced prostate cancer, for treatment decisions and family counseling. Dr. Pritchard highlights the clinical utility of both germline and somatic testing, especially in metastatic cases, and discusses the timing and types...

Medicare Data Compares Enzalutamide and Abiraterone Outcomes in mCRPC Patients - Dan George

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Zach Klaassen speaks with Dan George about a key study comparing Enzalutamide (Enza) and Abiraterone (Abi) in pre-chemotherapy metastatic castration-resistant prostate cancer (mCRPC). This study addresses a significant gap in head-to-head clinical trials for these drugs. Dr. George discusses various data sources, including the French National Database, Flatiron, and VA data, all indicating a survi...

Sequencing Therapies in Advanced Prostate Cancer Requires Balancing Many Factors - Rana McKay

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Alicia Morgans and Rana McKay delve into the complexities of treatment sequencing for metastatic castration-resistant prostate cancer. They highlight the expansive range of available therapies, including hormonal, targeted, immunotherapies, chemotherapy, and radioligand therapies. The focus is on the importance of patient involvement in decision-making, considering individual preferences, lifestyl...

Attacking Androgen Receptor From Two Sides: The Potential of a Novel Drug Duo in Prostate Cancer - Christos Kyriakopoulos

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Alicia Morgans interviews Christos Kyriakopoulos about a study presented at ESMO on EPI-7386, also known as masofaniten. Dr. Kyriakopoulos elaborates on this phase one-two study, which explores the combination of EPI-7386 with enzalutamide in patients with metastatic castration-resistant prostate cancer. EPI-7386 is novel in targeting the androgen receptor's N-terminal domain, differing from other...