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- Gerhardt Attard joins Ashley Ross in discussing an ancillary study of the STAMPEDE trial assessing the clinical qualification of transcriptome signatures for advanced prostate cancer starting ADT with or without abiraterone acetate and prednisolone. The addition of abiraterone acetate and prednisolone to ADT is the standard of care for advanced prostate cancer (metastatic, M1 and high-risk non-met...
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- Alicia Morgans converses with Matthew Smith and Kim Chi about the application of triplet therapy in metastatic hormone sensitive prostate cancer (mHSPC). Dr. Smith outlines the ARASENS study that tests the impact of adding darolutamide, an AR pathway inhibitor, to the standard treatment of androgen deprivation therapy (ADT) and docetaxel. The data suggest a significant survival advantage with trip...
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- At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC), Mary Ellen Taplin presents the role of systemic therapy in the treatment of patients with oligometastatic and oligoprogressive prostate cancer. Biographies: Mary Ellen Taplin, MD, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA Related Content: APCCC 2022: What Is the Evidence of Systemic Therapies (Alone or in Com...
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- At the 2022 Advanced Prostate Cancer Consensus Conference, Declan Murphy presents the impact of histology variants (ductal/intraductal/cribriform) on treatment recommendations. Biographies: Declan Murphy, MB, BCh, BaO, FRACS, FRCS Urol, Professor, Urologist & Director of GU Oncology, Peter MacCallum Cancer Centre, Associate Editor, BJUI, Honorary Clinical Professor, The University of Melbourne Rel...
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- Charles Ryan is joined by Neil Fleshner to discuss the efficacy and safety of radioligand 177Lu-PNT2002 in PSMA-positive patients with metastatic castration-resistant prostate cancer (mCRPC) who progressed after treatment with androgen receptor axis-targeted therapy (ARAT) in the SPLASH trial. Drs. Ryan and Fleshner start by discussing the issue of dosimetry and why it was important for the FDA to...
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- At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC), Emmanuel Antonarakis provided an update on the role of immune checkpoint inhibitors in the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC). Biographies: Emmanuel Antonarakis, MD, Clark Endowed Professor of Medicine, Division of Hematology, Oncology and Transplantation, University of Minnesota Rela...
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- Eric Small presents a discussion on primary small cell prostate cancer and therapeutic approaches to consider in aggressive variant prostate cancer (AVPC) and small cell neuroendocrine prostate cancer (t-SCNC) patients. Biographies: Eric Small, MD, Doris and Donald Fisher Distinguished Professorship in Clinical Cancer Research; Stanford W. Ascherman and Norman R. Ascherman Endowed Chair, UCSF, Pro...
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- At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC) Hybrid Meeting, Heather Cheng presents the importance of lifestyle and prevention of complications in advanced prostate cancer, focusing on how we should take care of our patient’s muscle strength. Biographies: Heather H. Cheng, MD, PhD, Director, Seattle Cancer Care Alliance Prostate Cancer Genetics Clinic, Division of Medical Onco...
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- Sigrid Carlsson joins Phillip Koo in a discussion on Smart Screening in Prostate Cancer, a session being highlighted at the upcoming 6th Global Summit on Precision Diagnosis and Treatment of Prostate Cancer taking place virtually September 22-24. The pair discuss challenges with screening today that require clinicians to be smarter about screening including the risk of overdiagnosis, incorporating...
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- Mark Rubin joins Alicia Morgans to discuss emerging therapies and emerging therapeutic targets in prostate cancer. Topics covered include types of resistance, epigenetic therapies, and EZH2 inhibitors. Dr. Rubin also shares his thoughts on how he sees molecular pathology impacting cancer care in the next decade. Biographies: Mark A. Rubin, MD, Professor, Principal Investigator, and Director of Dep...
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