Growth Hormone Deficiency Causing Micropenis: Lessons Learned From a Well-Adjusted Adult.

This report of a 46,XY patient born with a micropenis consistent with etiology from isolated congenital growth hormone deficiency is used to (1) raise the question regarding what degree testicular testosterone exposure to the central nervous system during fetal life and early infancy has on the development of male gender identity, regardless of gender of rearing; (2) suggest the obligatory nature of timely full disclosure of medical history; (3) emphasize that virtually all 46,XY infants with functional testes and a micropenis should be initially boys except some with partial androgen insensitivity syndrome; and (4) highlight the sustaining value of a positive long-term relationship with a trusted physician (R.

Relapse of Wilms' tumour and detection methods: a retrospective analysis of the 2001 Renal Tumour Study Group-International Society of Paediatric Oncology Wilms' tumour protocol database.

Wilms' tumour is the most common renal cancer in childhood and about 15% of patients will relapse. There is scarce evidence about optimal surveillance schedules and methods for detection of tumour relapse after therapy.

Distal Ureteral Diameter Ratio is Predictive of Breakthrough Febrile Urinary Tract Infection - Beyond the Abstract

Diagnosis and management of vesicoureteral reflux are difficult to treat to the high associated risk of recurrent tract infections and renal scarring. Because of this, treatment goals include prevention of febrile infections, avoidance of renal injury, and minimizing morbidity of treatment and follow-up.1 Children are at higher risk for recurrent pyelonephritis as well as potential sequelae from renal injury. The distal uretal diameter ratio (UDR) has high interrater reliability and has been shown to be predictive of spontaneous reflux resolution. The goal of this study was to evaluate UDR on initial diagnostic cystogram and risk of breakthrough febrile urinary tract infection (UTI).

The impact of surgical intervention on renal function in cystinuria.

Cystinuria is an autosomal recessive disorder due to intestinal and renal transport defects in cystine and dibasic amino acids, which result in recurrent urolithiasis and surgical interventions. This study aimed to assess the impact of surgical interventions on renal function by analyzing estimated glomerular filtration rates.

Bladder Rupture as a Complication of Circumcision following Total Subcoronal Urethral Ligation.

Circumcision is one of the most commonly performed procedures and generally is considered a safe and minor surgery. However, serious and catastrophic complications may sometime occur if adequate attention is not paid to all aspects of this procedure.

Pediatric calculi: cause, prevention and medical management.

The incidence of pediatric nephrolithiasis is on the rise, with a significant related morbidity and a concomitant relevant increase in healthcare costs. The purpose of the present review is to portray the current epidemiology and cause of renal stones in children, to provide a framework for appropriate clinical evaluation on an individual basis, and a guidance regarding treatment and prevention for the following significant risk of lifelong recurrence and deriving complications.

Bladder Agenesis and Associated Pelvic Arterial Anomaly in Two Female Pediatric Patients.

Bladder agenesis is an extremely rare congenital anomaly of the genitourinary tract. Two female patients with known diagnoses of bladder agenesis presented for pre-renal transplant evaluation and neobladder creation.

Urothelial carcinoma in children: A case series.

To report a series of 5 patients with urothelial bladder cancer (UBC) three of them with a history of exposure to amines and only two with gross hematuria.

After obtaining ethical and legal authorization, we performed a restrospective monocentric study.

Achieving urinary continence in cloacal exstrophy: The surgical cost.

Cloacal exstrophy (CE) is a severe midline congenital abnormality that requires numerous surgical corrections to achieve an acceptable quality of life. Candidates for urinary continence undergo multiple procedures, most often continent bladder diversions, to become socially dry.

Cystourethroscopy versus contrast studies in urogenital sinus and cloacal anomalies in children.

Cloacal malformation is a spectrum of diseases affecting females, resulting in abnormal confluence of the urinary system, genital system, and/or gastrointestinal system. Proper reconstruction depends mainly on accurate preoperative illustration of the abnormal anatomy.

Durasphere® EXP: a non-biodegradable agent for treatment of primary Vesico-Ureteral reflux in children.

Durasphere® EXP (DEXP) is a compound of biocompatible and non-biodegradable particles of zirconium oxide covered with pyrolytic carbon. The aim of this study is to evaluate the durability of off-label use of DEXP in the treatment of primary vesicoureteral reflux in children.

The Rise, Fall, and Resurrection of 11-Oxygenated Androgens in Human Physiology and Disease.

The 11-oxyandrogens, particularly 11-ketotestosterone, have been recognized as a biologically important gonadal androgen in teleost (bony) fishes for decades, and their presence in human beings has been known but poorly understood.

A Novel Calculator for Estimating Prostate Volume in Daily Urology Services.

To develop a simple prostate volume (PV) calculator which can aid in managing patients with lower urinary tract symptoms (LUTS) secondary to benign prostatic enlargement at daily urology services in developing Asian countries.

Safety of Tamsulosin: A Systematic Review of Randomized Trials with a Focus on Women and Children.

Although tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children.

46 XY Denys-Drash Syndrome. Is There a Role for Nephron Sparing Modalities in Management of Renal Masses? A Report of Two Cases.

Denys Drash Syndrome (DDS) is a combination of genital and urinary anomalies that mostly associated with renal and gonadal malignancies. We report 2 patients who presented with genital ambiguity and were diagnosed as 46XY DDS.

Do uroflowmetry and post - void residual urine tests necessary in children with primary nocturnal enuresis?

To examine the benefits of repetitive uroflowmetry and post void residual urine (PVR) tests in children with primary nocturnal enuresis (PNE).

Children aged ≥6 years with PNE who visited our clinics for management of enuresis were included for study.

Different managements for prepubertal epididymitis based on a preexisting genitourinary anomaly diagnosis.

There is no clear consensus regarding investigating for accompanying genitourinary anomalies (GUAs) in patients with prepubertal acute epididymitis (AE). Moreover, risk factors for the recurrence and the need for a surgical intervention have never been discussed.

Giant Renal Hemangioma in an Adolescent Girl - Beyond the Abstract

This case report is an important example of diagnostic challenges in adolescents with renal masses. The patient was a 15-year-old female who was admitted to our department for intermittent abdominal pain ongoing for 10 days. Her physical examination revealed a tender, easily palpable mass on the right upper quadrant. Her urinalysis was normal, hemoglobin level was 9.8 mg/dl and C-reactive protein level was high (136 mg/dl). Abdominal ultrasonography showed multicystic lesion located in the renal pelvis of the kidney with hyperechogenic solid components, 15.0 x 11.3 x 11.2 cm in size, showing vascularity on Doppler ultrasound imaging. Contrast enhanced abdominal computed tomography (CT) revealed 14.9 x 11.0 x 11.3 cm mass lesion located in the right renal hilum. The mass lesion has growth over parapelvic region compressing the renal parenchyma and the collecting system, exhibiting an enhancing capsule while having multicystic components with intralesional arteries larger than segmental renal arteries in size. Pre-operative differential diagnoses were cystic renal cell carcinoma, cystic Wilms’ tumor and multilocular cystic nephroma. Also no signs of metastases were present in thorax CT. Tumor markers were negative. Meanwhile, she developed fever (38 – 39oC) despite negative cultures.

Perinephric Urinoma Secondary to Malignancy in a Pediatric Patient.

Perinephric urinomas commonly arise following traumatic injury or high grade obstruction from kidney stones or lower urinary tract disorders. Not only are spontaneous urinomas rare in the pediatric population, but malignancy presenting with perinephric urinomas have only been described in the adult population.

Giant Renal Hemangioma in an Adolescent Girl: A Very Rare Entity.

Hemangiomas are benign vascular tumors of childhood and they usually tend to be located in the upper parts of the body (head and neck). However, renal hemangiomas are very rare and usually occur to be small (1-2 cm) in size.