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The RALU Study: Treatment Considerations in the First Line Setting of mCRPC
Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information
Videos
Conference Coverage
Conference Highlights Written by Physician-Scientist
SESAUA 2024: Time Interval Between Radium-223 Therapy and 177Lu-PSMA Treatment for mCRPC and Outcomes in the RALU Study
Presented by Alexander Chehrazi-Raffle, MD
The 2024 Southeastern Section of the AUA (SESAUA) annual meeting featured a prostate cancer session and a presentation by Dr. Alexander Chehrazi-Raffle discussing the time interval between Radium-223 therapy and 177Lu-PSMA treatment for mCRPC and outcomes in the RALU study. R Read More
ASCO GU 2023: Time Interval Between Radium‑223 Therapy and Lutetium-177–prostate-Specific Membrane Antigen (177Lu-PSMA) Treatment and Outcomes in the RALU Study
Presented by Kambiz Rahbar, MD
On the first day of the American Society for Clinical Oncology (ASCO) Genitourinary Cancer Symposium 2023 focussing on prostate cancer, Dr. Kambiz Rahbar presented data from the RALU trial in Poster Session A, examining the association between the time interval between sequential treatment with radium‑223 (223Ra) therapy and Lutetium-177–prostate-specific membrane antigen (177Lu-PSMA) and subsequent outcomes. Read More
ESMO 2022: Lutetium-177-PSMA Therapy in Patients with Prior Radium-223: Safety and Effectiveness Outcomes in the RALU Study
Presented by Kambiz Rahbar, MD
(UroToday.com) The 2022 ESMO annual meeting featured a prostate cancer session, including a presentation by Dr. Kambiz Rahbar discussing safety and effectiveness outcomes of 177Lu-PSMA therapy in patients with prior treatment with radium-223. Radium-223 is an established targeted alpha therapy with a good safety profile that prolongs overall survival (OS) and improves quality of life in patients with bone-predominant mCRPC. Read More
ASCO 2022: Safety and Survival Outcomes in Patients With mCRPC Treated With 177Lu-PSMA After Radium-223: Interim Analysis of the RALU Study
Presented by Kambiz Rahbar, MD
(UroToday.com) At the 2022 American Society of Clinical Oncology Annual Meeting held in Chicago and virtually, the poster session focused on Prostate, Testicular, and Penile cancers on Monday afternoon included a presentation from Dr. Kambiz Rahbar discussing sequential treatment with lutetium-177–prostate-specific membrane antigen (177Lu-PSMA) after radium-223 (223Ra) in men with metastatic castration-resistant prostate cancer (mCRPC). Read More
Publications
Commentaries that look beyond the published abstracts
177Lu-Prostate-Specific Membrane Antigen Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer and Prior 223Ra (RALU Study).
223Ra-dichloride (223Ra) and 177Lu-prostate-specific membrane antigen (PSMA) are approved treatments for metastatic castration-resistant prostate cancer (mCRPC). The safety and effectiveness of sequential use of 223Ra and 177Lu-PSMA in patients with mCRPC are not well described.
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Safety and Survival Outcomes of Lutetium-177-Prostate-Specific Membrane Antigen Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer with prior Radium-223 treatment: The RALU Study.
The RAdium LUtetium (RALU) study evaluated the feasibility of sequential alpha and beta emitter use in patients with bone-predominant metastatic castration-resistant prostate cancer.
This pre-planned, interim, retrospective analysis investigated safety and survival outcomes with lutetium-177-PSMA (177Lu-PSMA) in patients treated with prior radium-223 (223Ra).
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This pre-planned, interim, retrospective analysis investigated safety and survival outcomes with lutetium-177-PSMA (177Lu-PSMA) in patients treated with prior radium-223 (223Ra).
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