Centers of Excellence
The Latest Research on CRPC with Bone Metastases
Contrary to your initial reaction, the title for this blog is not an illusion to that ingenious remake of the stationary bike. The vicious cycle I am referring to is instead the positive feedback loop between prostate adenocarcinoma cells and osteocytes resulting in growth of both cellular compartments and ultimately the formation of bone metastases. While metastases can occur in many organ systems, there is a disproportionate frequency and number of bone metastases in prostate cancer, which drive much of the morbidity of this disease. For many patients, bone metastases are the only site of disease spread, and the vicious cycle is likely the culprit for this pattern.
Daniel George, MD is Professor of Medicine and Surgery, Divisions of Medical Oncology and Urology in the Duke University School of Medicine and leads the Duke Prostate and Urologic Cancer Center. He also has appointments in the Duke Clinical Research Institute and the Duke Cancer Institute where he is the Director of Genitourinary (GU) Oncology. Daniel George has led the Duke site for the Department of Defense (DOD) Prostate Cancer Clinical Trials Consortium since 2006.