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Genomic Classifier in Prostate Cancer: Intermediate-Risk

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Genomic Biomarker Testing

Presented by Ugo De Giorgi, MD, PhD
Ugo De Giorgi, MD, PhD, presented a post hoc analysis from the phase 3 TALAPRO-2 trial evaluating the impact of baseline demographic characteristics on talazoparib (TALA) dose modifications and clinical outcomes among patients with metastatic castration-resistant prostate cancer (mCRPC) treated with talazoparib plus enzalutamide (ENZA).

ARANOTE

Presented by Zachary Klaassen, MD, MSc
The 2026 Southeastern Section of the AUA Annual Meeting featured a presentation by Dr. Zachary Klaassen of a post hoc analysis from the phase 3 ARANOTE trial evaluating darolutamide plus androgen-deprivation therapy (ADT) versus placebo plus ADT in patients with metastatic hormone-sensitive prostate cancer (mHSPC), with outcomes stratified by disease volume.

Trials in Progress

  Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information

MEVPRO-3 Trial

Presented by Neeraj Agarwal, MD, FASCO
Neeraj Agarwal, MD, FASCO, discussed MEVPRO-3, a phase III trial of mevrometostat + enzalutamide versus placebo + enzalutamide in mCSPC. Enhancer of zeste homolog 2 (EZH2) enzymatic activity plays a crucial role in prostate cancer progression. Mevrometostat, an oral potent and selective EZH2 inhibitor, may synergize with androgen receptor pathway inhibitors to delay androgen receptor pathway inhibitor resistance.

MEVPRO-1 & 2 Trial

Presented by Nobuaki Matsubara, MD
The 2026 ASCO GU cancers symposium held in San Francisco, CA, was host to the Poster Session A: Prostate Cancer. Dr. Nobuaki Matsubara presented Poster 195: Efficacy and safety of mevrometostat in combination with enzalutamide in patients with mCRPC: Data from a phase 1 study.