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Advanced Bladder Cancer

Beyond Androgen Blockade - Exploring New Pathways for Treating mCRPC and mHSPC

APCCC 2024

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EMBARK

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Advanced Bladder Cancer
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PSMA-Targeted Therapy
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Transformative Evidence

  Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information

ANKTIVA

  • U.S. Urology Partners is one of the first providers to offer patients ImmunityBio’s recombinant Bacillus Calmette-Guérin (rBCG)
  • The FDA recently authorized ImmunityBio’s EAP for rBCG to address U.S. shortages and provide an alternative source of BCG, a critical standard-of-care in bladder cancer
  • Multiple urology centers across the U.S. are in the process of activating their sites to administer rBCG
Reno, Nevada (UroToday.com) -- ImmunityBio, Inc. (NASDAQ: IBRX), a leading immunotherapy company, announced U.S. Urology Partners, one of the nation’s largest independent providers of urology and related specialty services, is one of the first providers to participate in ImmunityBio’s Expanded Access Program (EAP) for recombinant Bacillus Calmette-Guérin (rBCG) to address the current shortage of TICE® BCG in the U.S.

ARANOTE

Presented by Fred Saad, MD, FRCS
 The 2025 GU ASCO annual meeting featured a prostate cancer session and a presentation by Dr. Fred Saad discussing a subgroup analysis of the phase 3 ARANOTE trial assessing darolutamide + ADT in patients with metastatic hormone-sensitive prostate cancer (mHSPC) by disease volume. Darolutamide + ADT significantly reduced the risk of radiological progression or death by 46% (HR 0.54, 95% CI 0.41–0.71; p < 0.0001) versus placebo plus ADT in patients with mHSPC in the ARANOTE trial.

Trials in Progress

  Curated by Clinicians: Educational Forum with Videos, Abstracts and Conference Information

CORE-008 Trial

Presented by Trinity Bivalacqua, MD
The 2025 GU ASCO annual meeting featured a urothelial carcinoma trials in progress session and a presentation by Dr. Trinity Bivalacqua discussing CORE-008, a phase 2, multi-arm, multi-cohort, open-label study to evaluate intravesical cretostimogene grenadenorepvec in participants with high-risk non-muscle invasive bladder cancer.

CLARIFY Trial

Presented by Michael A. Gorin, MD
 The 2025 GU ASCO annual meeting featured a prostate cancer trials in progress session and a presentation by Michael Gorin discussing CLARIFY, a phase 3 diagnostic performance study assessing PET using 64Cu-SAR-bisPSMA in patients with high-risk prostate cancer prior to radical prostatectomy. Prostate cancer is the second most prevalent cancer in men globally. In men with newly diagnosed, high-risk disease, prostate cancer most often spreads to the pelvic lymph nodes before becoming widely metastatic.