Li and colleagues designed and built an in vitro continuous flow model to test the incrustation. Artificial urine formulated by Tunney et al was chosen. Experiments were run for a 5-day period with daily urine refresh. Each material was run twice to ensure stability of results and calcium encrustation was measured via o-Cresolphalein method.
After the 10-day series of each material Li et al ran Fisher’s exact tests and ANOVA were performed to determine statistical differences. The study team found that polyether has a consistently lower rate of encrustation, maintaining linear growth for a max of ~11 mg/mm2. Polyester and Aromatic polyester were also found to have a significantly lower rate of encrustation maxing out at ~15 mg/mm2 each.
Li suggests the use of polyester and aromatic polyester could be beneficial to flow dynamics for patients receiving indwelling stents and/or catheters. He also explains that the study team was able to develop a reliable assay for stone encrustation evaluation. Li also concluded that the use of silicone as the standard should be further investigated considering their results.
Presented By: Gary Li, Tufts University Cambridge, Massachusetts, USA
Author(s): Gary Li, Jun Li, Zheng Zhang, Morgan Tierney, Cambridge, MA
Affiliation: Tufts University Cambridge, Massachusetts
Written By: Anthony Warner, a research intern from the University of California, Irvine, on behalf of UroToday.com.
at the 2017 AUA Annual Meeting - May 12 - 16, 2017 – Boston, Massachusetts, USA