Centers of Excellence
The Latest Research on mCRPC Treatment
In the summary slide of one of my 'go-to' talks I pose the question “Have we reached the limits of androgen receptor (AR) targeting?”. Of course, I don’t know the answer, which is precisely why it is framed in the form of a question on a summary slide. But I think about it a lot. So, let’s ponder this question a little.
Charles J. Ryan, MD is the B.J. Kennedy Chair in Clinical Medical Oncology at the University of Minnesota and Director of the Division of Hematology, Oncology and Transplantation. He previously held the position of Professor of Clinical Medicine and Urology and the Clinical Program Leader for Genitourinary Medical Oncology at the UCSF Helen Diller Family Comprehensive Cancer Center
Protecting and improving bone health is critical when managing all stages of prostate cancer. Androgen deprivation therapy (ADT) accelerates bone resorption, which compromises bone mass and integrity starting early in treatment.1 Metastatic prostate cancer is associated with a marked increase in risk of skeletal events (fracture, spinal cord compression, and bone surgery or radiotherapy) associated with both bone metastases and treatment-induced bone loss.