AUA 2017: Best Abstract – Focal therapy of prostate cancer: Defining appropriate treatment margins using MRI: whole mount co-registration
Boston, MA (UroToday.com) In this session, Dr. Jones explained the UCLA initial experience with defining treatment margins for focal therapy. Thirty-five men with Gleason score 4+3=7 tumors visible on MRI were included and all underwent radical prostatectomy. MRI contouring of prostate specimens was performed and 3D patient-specific molds were created. The specimen was then aligned with the MRI, and tumors were matched with MRI regions of interest. The median treatment margin required was 10.7mm and the average treatment volume required was 11.4 cm3 (30% average prostate volume). MRI categorically underestimated the size of prostate tumors relative to matched prostatectomy specimens (1.59 cm3 on whole mount versus 0.59 cm3 on MRI, p < 0.001). All men would have been successfully treated with hemi-gland ablation. Dr. Jones concluded that MRI underestimates the extent of prostate tumors and emphasized that future priorities are to develop patient-specific treatment plans that incorporate tumor size, geometry, and adjacent tissue sampling.
Presented By: Tonye Jones, MD
Written By: Benjamin T. Ristau, MD, Fox Chase Cancer Center, Philadelphia, PA
at the 2017 AUA Annual Meeting - May 12 - 16, 2017 – Boston, Massachusetts, USA