AUA 2017: Impact of prostate involvement on outcomes in patients treated with radical cystoprostatectomy for bladder cancer

Boston, MA ( This single-institutional retrospective study found prostatic stromal invasion by urothelial carcinoma to be associated with worse survival outcomes. In 893 men undergoing RC, 181 were found to have prostatic urethral involvement. Of those, 75 had urethral/duct involvement, while 106 had stromal involvement. Prostatic stromal invasion was identified to be a significant predictor of recurrence and cancers-specific survival on multivariate analyses.

These results confirm the evidence used to compile the AJCC TNM classification, in which prostatic stromal invasion alone was categorized as pT4 disease. The study highlights the importance of careful pathologic evaluation to differentiate prostatic stromal invasion from ductal/urothelial invasion. Although this clinical phenomenon has been well described, the biology behind prostatic stromal invasion remains elusive. Future studies assessing the molecular features driving prostatic stromal spread would be of interest.

Presented by: Marco Moschini MD

Written By: Roger Li MD Urologic Oncology Fellow, Department of Urology, UT MD Anderson Cancer Center, Houston, TX
Ashish M. Kamat MD Wayne B. Duddlesten Professor, Department of Urology, UT MD Anderson Cancer Center, Houston TX

at the 2017 AUA Annual Meeting - May 12 - 16, 2017 – Boston, Massachusetts, USA