Precision Medicine in Prostate Cancer VL

TheraP Trial Design Evaluating 177Lu‐PSMA‐617 Theranostic Treatment vs Cabazitaxel in Progressive Metastatic Castration‐Resistant Prostate Cancer - Michael Hofman

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Michael Hofman, from the Peter MacCallum Cancer Centre in Melbourne, Australia joins Charles Ryan to go "beyond the VISION Trial" discussing ongoing clinical trials with lutetium, for example, TheraP: a randomized phase 2 trial of 177Lu‐PSMA‐617 theranostic treatment vs cabazitaxel in progressive metastatic castration‐resistant prostate cancer (Clinical Trial Protocol ANZUP 1603) where results are...

Genetically Informed Treatment for Advanced and Metastatic Prostate Cancer - Alicia Morgans

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Alicia Morgans, Associate Professor of Medicine at Northwestern University, shares her thoughts on genetically informed treatment for advanced and metastatic prostate cancer. Germline and somatic testing can have implications for patients in terms of their therapeutics and the main mutations. Morgans discusses the important germline and somatic mutations as well as the current data from clinical t...

Targeted Molecular Therapies for Treatment of Advanced Prostate Cancer - Scott Tagawa

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Scott Tagawa joins Alicia Morgans in discussing his recent research focus on radiopharmaceuticals for the treatment of prostate cancer. Dr. Tagawa highlights his studies evaluating both beta-emitting particles and alpha targeted particle therapies. Biographies: Scott T. Tagawa, MD, Associate Professor of Clinical Medicine, Clinical Urology, Medical Director, Genitourinary Oncology Research Program...

Imaging and Flare Responses When Assessing Patients with Metastatic Castration-Resistant Prostate Cancer - Anwar Padhani

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Anwar Padhani discusses his presentation from the 2019 Advanced Prostate Cancer Consensus Conference (APCCC) on the flare phenomenon in advanced prostate cancer. Because of this phenomenon, clinicians have created workarounds. Dr. Padhani expands that there are multiple consequences of the workarounds, one being that they cause delays in the treatment schedule. Precision oncology trials require ra...

Outcomes of Patients From PSMA Targeted Radionuclide Trials - Panagiotis Vlachostergios

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Panagiotis Vlachostergios, MD, Ph.D., describes a study that he conducted reviewing the outcomes of patients who participated in PSMA targeted radionuclide trials over the past 18 years. Dr. Vlachostergios generated a visual score of PSMA expression to determine an association with response to PSMA-radio-nucleotide targeted therapies. Higher PSMA expressers showed an association with PSA response....

Integrating Germline and Somatic Mutations Tests into Clinical Practice Workflows - Wassim Abida

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Wassim Abida, MD, describes his work to facilitate both better understanding of the genomic landscape of prostate cancer while simultaneously integrating new genomic information into clinical practice. In a conversation with Alicia Morgans, MD, MPH, Dr. Abida describes how to identify the subsets of patients that serve to benefit from targeted therapies, referencing the use of pembrolizumab for MS...

High Activity Pain Reduction and Low Toxicity with Lu177 PSMA617 Theranostics - Michael Hofman

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Professor Michael Hofman presents details of a phase II prospective study on lutetium-PSMA-617. This study used the diagnostic companion of gallium-PSMA-11 to select patients with a high PSMA expression that were suitable for lutetium-PSMA-607 therapy. This was a prospective study. It was a 30 patient study and the results of that initial cohort were published in Lancet Oncology. This was followed...

The VISION Trial: Radionuclide Therapy Plus Standard Therapy for Metastatic Castration Resistant Prostate Cancer - Oliver Sartor and Michael Morris

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At the 26th Annual Prostate Cancer Foundation Scientific Retreat (PCF 2019), Oliver Sartor and Michael Morris join Charles to discuss lutetium in advanced prostate cancer and the VISION trial. Dr. Michael Morris serves on the scientific oversight committee of the trial, and Dr. Sartor is one of the co-PIs of this clinical trial. The VISION trial has the potential to change clinical practice in the...

177LU-PSMA-617 in the Treatment of Patients with Progressive PSMA-Positive Metastatic Castration-Resistant Prostate Cancer - Oliver Sartor

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Professor of Medicine Oliver Sartor from Tulane University joins Charles Ryan to discuss several lutetium studies, radioligand therapy, and the VISION trial and where the state of lutetium currently stands both in the United States and globally with radiopharmaceutical treatment options. Biographies: A. Oliver Sartor, MD, Professor of Medicine and Medical Director, Tulane Cancer Center; C. E. and...

A Study of 177Lu-PSMA-617 In Metastatic Castrate-Resistant Prostate Cancer - The VISION Trial, Interview with Oliver Sartor

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Oliver Sartor joins Charles Ryan to talk about the VISION trial, a trial testing the PSMA-617 agent, The novel therapeutic drug 177Lu-PSMA-617 is a prostate-specific membrane antigen (PSMA) targeting agent to deliver radionuclide therapy for the treatment of patients with metastatic castration-resistant prostate cancer (mCRPC). The primary objective of this study is to compare the 2 alternative en...