Journal Club VL

The Efficacy and Safety of Abiraterone Plus Prednisone, With or Without Radiotherapy, in Addition to Standard of Care (PEACE-1): Journal Club – Christopher Wallis & Zachary Klaassen

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In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the PEACE-1 Lancet publication Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design. The efficacy and safety of abiraterone plus prednisone,...

5-Year Follow-Up Results From the STAMPEDE Randomised Trial: Abiraterone Acetate Plus Prednisolone for Metastatic Patients Starting Hormone Therapy: Journal Club – Christopher Wallis & Zachary Klaasse...

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In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the International journal of cancer publication Abiraterone acetate plus prednisolone for metastatic patients starting hormone therapy: 5-year follow-up results from the STAMPEDE randomised trial. Abiraterone acetate plus prednisolone previously showed a clear survival advantage in men starting long-term hormone therap...

The Underrepresentation of Black and Hispanic Men in Clinical Trials Compared With Their Share of Prostate Cancer Incidence: Journal Club – Christopher Wallis & Zachary Klaassen

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In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the JAMA oncology publication Disparities in the Inclusion of Racial and Ethnic Minority Groups and Older Adults in Prostate Cancer Clinical Trials: A Meta-analysis. Mandates have been put in place to emphasize both the importance of including racial and ethnic minorities in clinical trials and the reporting of the dem...

What Urologists Need to Know: mpMRI for the Detection of Clinically Significant Prostate Cancer Journal Club - Christopher Wallis & Zachary Klaassen

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In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the European urology publication titled "Multiparametric Magnetic Resonance Imaging for the Detection of Clinically Significant Prostate Cancer: What Urologists Need to Know. Part 2: Interpretation." It is generally felt that MRI is superior to other imaging techniques, including CT scans, for soft tissue assessment. T...

SALV-ENZA Trial: Salvage Radiation Therapy Plus Enzalutamide or Placebo for High-Risk Prostate-Specific Antigen Recurrent Prostate Cancer After Radical Prostatectomy Journal Club - Christopher Wallis...

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In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the Journal of clinical oncology publication of the phase II SALV-ENZA Trial which sought to investigate whether enzalutamide, without concurrent androgen deprivation therapy, increases freedom from prostate-specific antigen progression when combined with salvage radiation therapy in men with recurrent prostate cancer...

Treatment-Specific Out-of-Pocket Costs for Patients Undergoing Localized Prostate Cancer Journal Club - Christopher Wallis & Zachary Klaassen

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In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the Urologic Oncology publication entitled Out-of-pocket costs for commercially insured patients with localized prostate cancer. Financial burdens may contribute to long-term effects on patient's health-related quality of life. However, costs are rarely included in shared decision-making conversations, and most studies...

Differences in Mental Health Outcomes According to the Treatment Received for Men Being Treated with Localized Prostate Cancer Journal Club - Christopher Wallis & Zachary Klaassen

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Christopher Wallis and Zachary Klaassen discuss The Journal of Urology publication entitled "Association Between Treatment for Localized Prostate Cancer and Mental Health." This study compares patient-reported mental health outcomes for men undergoing treatment for localized prostate cancer over 5 years using the Comparative Effectiveness Analysis of Surgery and Radiation (CEASAR) study. Biographi...

Using MRI to Safely Prevent Unnecessary Protocol-Advised Repeat Biopsy During Active Surveillance Journal Club - Christopher Wallis & Zachary Klaassen

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In this UroToday Journal Club, Chris Wallis and Zach Klaassen highlight a European Urology Oncology publication entitled Multivariable Approach Using Magnetic Resonance Imaging to Avoid a Protocol-Based Biopsy in Men on Active Surveillance for Prostate Cancer -- Data from the Multi-International Multicenter Prospective PRIAS Study . In general, the use of MRI prior to initial biopsy is now relativ...

Comparing the Relative Benefits of Radiotherapy Dose Escalation ± Short-Term or Long-Term ADT as Treatment Intensification for Localized Prostate Cancer Journal Club - - Christopher Wallis & Zachary K...

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In this UroToday Journal Club, Chris Wallis and Zach Klaassen highlight a European Urology publication entitled High-dose Radiotherapy or Androgen Deprivation Therapy (HEAT) as Treatment Intensification for Localized Prostate Cancer: An Individual Patient-data Network Meta-analysis from the MARCAP Consortium . Radiotherapy is a standard-of-care treatment approach for patients with localized prosta...

Improvement in rPFS with Abiraterone Plus Olaparib Over Abiraterone Plus Placebo in First-Line mCRPC Irrespective of HRR Mutation Status, The PROpel Trial Journal Club - Christopher Wallis & Zachary K...

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In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen review the PROpel study and the New England Journal of Medicine Evidence publication entitled Abiraterone and Olaparib for Metastatic Castration-Resistant Prostate Cancer . PROpel is a randomized phase III trial of abiraterone plus olaparib versus abiraterone plus placebo as first-line therapy for patients with metastatic castr...
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