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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the Prostate Cancer and Prostatic Diseases publication entitled, " Association of dynamic change in patient-reported pain with survival in metastatic castrate-sensitive prostate cancer-exploratory analysis of LATITUDE study. " In addition to overall survival, it is important to consider other endpoints. Patient-reported...
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- In this UroToday Journal Club discussion, Christopher Wallis and Zachary Klaassen discuss the publication " The Addition of Docetaxel to Androgen Receptor Axis-Targeted Therapy and ADT in Metastatic Hormone-Sensitive Prostate Cancer: A Network Meta-Analysis ." There is a clinical conundrum in that while the triplet approaches in both PEACE-1 and ARASENS have proven benefits compared to the ADT-doc...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the European urology publication Efficacy and Safety of Darolutamide in Patients with Nonmetastatic Castration-resistant Prostate Cancer Stratified by Prostate-specific Antigen Doubling Time: Planned Subgroup Analysis of the Phase 3 ARAMIS Trial. Darolutamide is one of three agents that's been assessed in this space, an...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the Journal of Clinical Oncology publication Sequencing of Androgen-Deprivation Therapy of Short Duration With Radiotherapy for Nonmetastatic Prostate Cancer (SANDSTORM): A Pooled Analysis of 12 Randomized Trials led by the MARCAP Consortium. The SANDSTORM meta-analysis evaluated the sequencing of short-term androgen de...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the Lancet Oncology publication Patient-reported outcomes with olaparib plus abiraterone versus placebo plus abiraterone for metastatic castration-resistant prostate cancer: a randomised, double-blind, phase 2 trial. In this publication, the exploratory analysis of pain and health-related quality of life (HRQOL) is pres...
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- In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the PEACE-1 Lancet publication Abiraterone plus prednisone added to androgen deprivation therapy and docetaxel in de novo metastatic castration-sensitive prostate cancer (PEACE-1): a multicentre, open-label, randomised, phase 3 study with a 2 × 2 factorial design. The efficacy and safety of abiraterone plus prednisone,...
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- In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the International journal of cancer publication Abiraterone acetate plus prednisolone for metastatic patients starting hormone therapy: 5-year follow-up results from the STAMPEDE randomised trial. Abiraterone acetate plus prednisolone previously showed a clear survival advantage in men starting long-term hormone therap...
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- In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the JAMA oncology publication Disparities in the Inclusion of Racial and Ethnic Minority Groups and Older Adults in Prostate Cancer Clinical Trials: A Meta-analysis. Mandates have been put in place to emphasize both the importance of including racial and ethnic minorities in clinical trials and the reporting of the dem...
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- In this UroToday Journal Club, Christopher Wallis and Zachary Klaassen discuss the publication titled Shorter Radiation Regimens and Treatment Non-Completion Among Patients with Breast and Prostate Cancer in the United States: An Analysis of Racial Disparities in Access and Quality. The goal of this analysis is to assess trends in the uptake of shorter radiation regimes with a focus on the data fo...
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- In this UroToday Journal Club Christopher Wallis and Zachary Klaassen highlight the European urology publication titled "Multiparametric Magnetic Resonance Imaging for the Detection of Clinically Significant Prostate Cancer: What Urologists Need to Know. Part 2: Interpretation." It is generally felt that MRI is superior to other imaging techniques, including CT scans, for soft tissue assessment. T...
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