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- Ashish Kamat interviews Chris Garris, the 2023 Bladder Cancer Research Innovation Award recipient. Dr. Garris discusses his pioneering research project aimed at overcoming immune suppressive myeloid cell barriers in bladder cancer through immune agonism. He presents the CANDI therapeutic platform which uses IL-12-inducing drug combinations to stimulate immune responses for potentially more effecti...
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- Andrew Hsieh highlights his team's research on a new tumor suppressor mechanism termed transcriptional-translational conflict. The research primarily focuses on ARID1A, a component of the SWI/SNF chromatin remodeling complex, which is frequently deregulated in bladder cancer. In absence of ARID1A, up-regulated oncogenic gene networks were observed, but no tumorigenesis occurred due to a conflict b...
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- Zach Klaassen and Kevin Gallagher discuss the RESECT study. RESECT, a global research initiative across five continents and over 200 hospitals, aims to improve the quality of Transurethral Resection of Bladder Tumor (TURBT) surgery and reduce early recurrence rates. Funded in 2020 and launched in late 2020-early 2021, the study utilizes social media marketing and is run on a low budget. It include...
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- Ashish Kamat converses with Alexandre Zlotta on his study comparing radical cystectomy and trimodal therapy (TMT) for muscle-invasive bladder cancer. Dr. Zlotta highlights the evolving treatment paradigm towards organ preservation with TMT, a method combining limited resection and chemoradiation. Despite the mounting evidence for TMT, it is typically reserved for patients ineligible for surgery. D...
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- Seth Lerner presents the results of a SWOG-led Phase III surgical trial (SWOG S1011) investigating the anatomic extent of node dissection during radical cystectomy for curable muscle invasive bladder cancer. The primary goal was to compare disease-free survival (DFS) in patients undergoing cystectomy, contrasting an extended node dissection with standard pelvic lymphadenectomy. After a median six...
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- Ashish Kamat welcomes Max Kates and Petros Grivas, the chair and incoming chair of the review committee for BCAN's Travel Fellowship. Dr. Grivas explains that the committee had an extremely difficult task this year due to the high-quality applications they received, which showcased talented fellows, residents, and their remarkable mentors. He also highlights the structured selection process that t...
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- In this discussion, Ruchika Talwar spotlights the crucial research of Valentina Grajales. Driven by a personal experience with her father's prostate cancer diagnosis and consequent depression, Dr. Grajales explores the incidence of mental health illness in non-muscle invasive bladder cancer patients. Her research, using the SEER-Medicare dataset, found a reduced incidence of mental health issues i...
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- Ashish Kamat invites Joshua Meeks to discuss his ground-breaking research on immunotherapy for bladder cancer. Dr. Meeks sheds light on his work in identifying genotypes and phenotypes that impact patient response, drawing insights from the significant PURE-01 and ABACUS studies. His team discovers variations in tumor microenvironments and cells that may influence drug activity, suggesting that sp...
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- Ashish Kamat welcomes Peter Goebell to discuss the 25-year trajectory of the International Bladder Cancer Network (IBCN). Tracing the organization's evolution from an NIH-backed project in Barcelona to a globally recognized entity, they highlight notable achievements including a seminal p53 immunohistochemistry paper and a successful SPORE grant application for a tissue microarray project. Dr. Goe...
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- Ashish Kamat invites Tahlita Zuiverloon to discuss her study on non-muscle invasive bladder cancer (NMIBC) and predicting responses to intravesical BCG treatment. Dr. Zuiverloon's study employed whole-transcriptomic sequencing to analyze pre- and post-BCG tumors from 283 patients across five European urological centers, aiming to identify molecular subtypes predictive of BCG responses. The study i...
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