Bladder Cancer VL

Management Trends & Outcomes of Patients Undergoing Radical Cystectomy for Urothelial Carcinoma, the USC Experience - Anirban Mitra

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Anirban P Mitra joins Ashish Kamat in highlighting the University of Southern California's experience in the management trends and outcomes of patients undergoing radical cystectomy for urothelial carcinoma of the bladder. This has been updated to reflect current practice patterns, including neoadjuvant, adjuvant therapy, and stage migration. This study looked at clinical-pathological as well as o...

Comparative Effectiveness Of Neoadjuvant Chemotherapy In Bladder And Upper Urinary Tract Urothelial Carcinoma - Jeffrey Holzbeierlein

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Sam Chang and Jeffrey Holzbeierlein discuss the comparative effectiveness of neoadjuvant chemotherapy for bladder cancer, as well as for upper urinary tract urothelial carcinoma. Dr. Holzbeierlein goes into depth on the background of neoadjuvant treatment for these diseases, as well as a look at the POUT trial. They also discuss future projects and exciting new studies. Biographies: Jeffrey Holzbe...

Preventing Recurrence of Urothelial Carcinoma in Patients with Upper Tract Carcinoma - Aditya Bagrodia

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In this discussion with Ashish Kamat on the prevention of bladder recurrence, Aditya Bagrodia starts off with a case study of a 69-year-old female in generally good health, presents with hematuria, well-controlled diabetes, hypertension, remote history of smoking, and importantly, no history of upper tract urothelial cancer in the family or other Lynch syndrome-associated malignancies. Drs. Bagrod...

Surveillance Guidelines for Low-Grade Ta NMIBC Often Not Followed - Stephen Williams

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Low-risk non-muscle-invasive bladder cancer (NMIBC) is associated with extremely low rates of progression and cancer-specific mortality; however, patients with low-risk NMIBC may often receive non-guideline-recommended and potentially costly surveillance testing and treatment. The objective of this study was to describe current surveillance and treatment practices, cancer outcomes, and costs of ca...

Microbiome Research in Bladder Cancer - Laura Bukavina

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Ashish Kamat is joined by Laura Bukavina to discuss her work on the Microbiome of Bladder Cancer. Currently, we have little knowledge about the microbiome and bladder cancer. The research being done at Fox Chase and Case Western is comparing the beta diversity of bladder cancer patients compared to healthy controls to help think of ways to modulate the microbiome to improve the treatment of patien...

Realities of Bladder Cancer In Women - Sima Porten, Kristen Scarpato, Svetlana Avulova & Anne Schuckman

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Kristen Scarpato, Svetlana Avulova, and Anne Schuckman join Sima Porten in this conversation on the realities of diagnosis and treatment of bladder cancer in women. They start by evaluating a patient case to highlight some women who present with bladder cancer and discuss what's most important when we talk about caring for these patients and how to improve care. Biographies: Sima P. Porten, MD, MP...

Busting Common Myths Regarding Bladder Preservation for Muscle Invasive Bladder Cancer - Nick James & Ananya Choudhury

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Ashish Kamat, Ananya Choudhury, and Nick James discuss trimodal therapy, or radiotherapy, for bladder preservation in patients with bladder cancer. Dr. Choudhury touches on how to differentiate treatment between moving towards cystectomy and deciding on radiotherapy. They also discuss differing radiotherapy schedules and how those differences can affect patients. Biographies: Ananya Choudhury, MA,...

Urethral Recurrence after Radical Cystectomy for Bladder Cancer - Ekaterina Laukhtina

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Ekaterina Laukhtina and Ashish Kamat discuss urethral recurrence after radical cystectomy. Dr. Laukhtina goes into depth on using urethroscopy to diagnose urethral recurrence as well as when urethrectomy may be useful highlighting a systematic review and meta-analysis assessing the incidence and risk factors of urethral recurrence as well as summarizing data on survival outcomes in patients with u...

The Role of Bladder-Sparing Trimodality Therapy - Sophia Kamran

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Sophia Kamran joins Sam Chang to discuss her presentation from the GU ASCO 2022 Annual Meeting focusing on novel therapies in bladder cancer and their toxicities, discussing the role of bladder-sparing trimodality therapy with a focus on toxicity and functional outcomes. Biographies: Sophia C. Kamran, MD, Assistant Professor of Radiation Oncology, Harvard Medical School, Massachusetts General Hosp...

Biological Pathways in Urothelial Carcinoma - Carissa Chu

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Carissa Chu joins Sam Chang to discuss data on genetic changes and alterations in urothelial carcinoma. The purpose of the study is to characterize human epidermal growth factor receptor 2 (HER2) (ERBB2) and fibroblast growth factor receptor 3 (FGFR3) mutations in a prospectively collected cohort of urothelial cancers. Dr. Chu highlights the key findings from this study. Biographies: Carissa Chu,...
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