Similar to multiparametric magnetic resonance imaging, multiparametric ultrasound (mpUS) can represent a promising approach for prostate cancer (PCa) imaging. We determined the diagnostic performance of B-mode, shearwave elastography (SWE), contrast-enhanced ultrasound (CEUS) with quantification software, and their combination, mpUS, for clinically significant (cs)PCa localization using radical prostatectomy (RP) histopathology as reference standard.