Addiction to opium continues to be a major worldwide medical and social problem.
The study addressing the association between opium consumption and serum prostate-specific antigen (PSA) level is lacking. We determined the effects of opium consumption on serum PSA levels in opium-addict men. Our study subjects comprised 438 opium-addict men with a mean age of 52.2 ± 6.4 years (group 1). We compared these men with 446 men who did not indicate current or past opium use (group 2). Serum total PSA (tPSA), free PSA (fPSA), % fPSA, and sex hormones were compared between the 2 groups. The mean serum tPSA level was significantly lower in group 1 (1.05 ng/mL) than in controls (1.45 ng/mL) (P = 0.001). Opium consumption was also associated with lower fPSA (P = 0.001) and % fPSA (P = 0.001). Serum free testosterone level in opium-addict patients (132.5 ± 42 pg/mL) was significantly lower than that in controls (156.2 ± 43 pg/mL) (P = 0.03). However, no significant correlation existed between tPSA and free testosterone levels (r = 0.28, 95% CI, -0.036 to 0.51, P = 0.34). Among the patients with cancer in group 1, 35% were found to have high-grade tumor (Gleason score ≥ 7) compared with 26.7% in group 2 (P = 0.02). Total PSA and fPSA were strongly correlated with duration of opium use (r = -0.06, 95% CI, -0.04 to -0.08, P = 0.0001; and r = -0.05, 95% CI, -0.03 to -0.07, P = 0.0001, respectively). Opium consumption is independently and negatively associated with serum tPSA, fPSA, and % fPSA levels.
Written by:
Safarinejad MR, Asgari SA, Farshi A, Iravani S, Khoshdel A, Shekarchi B. Are you the author?
Clinical Center for Urological Disease Diagnosis, Tehran, Iran; Urology Research Center, Guilan University of Medical Sciences, Rasht, Iran; Department of Urology, Tabriz University of Medical Sciences, Tabriz, Iran; and Research Center, Department of Biotechnolog, Research Center, Departments of Clinical Epidemiology, and Research Center, Department of Radiology, Medical Faculty, AJA University of Medical Sciences, Tehran, Iran.
Reference: J Addict Med. 2013 Jan 4. Epub ahead of print.
doi: 10.1097/ADM.0b013e31827b72d9
PubMed Abstract
PMID: 23296201
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