OBJECTIVE:The aim of this retrospective study was to investigate the association between the pretreatment apparent diffusion coefficient (ADC) value and recurrence of bladder cancer after transurethral resection.
METHODS:Patients with superficial bladder cancer were identified. Mean ADC values of the tumors were compared between patients with and without recurrence following trans-urethral resection. A receiver-operator characteristic curve was used for determining the optimal cutoff ADC value. Univariate and multivariate analyses were used to determine the effect of ADC values and other factors.
RESULTS: With a mean follow-up period of 25 months, bladder cancer recurred in 14 of 44 patients (32%). The mean ADC value of tumors in patients with recurrence was lower than in those without recurrence (1.08mm2/s vs. 1.28×10-3mm2/s; p=0.003). The optimal cutoff ADC value for predicting recurrence was determined to be 1.12×10-3mm2/s. A modest and significant negative correlation was observed between the ADC values and tumor size (r=-0.436, p=0.008). After adjustment for size and risk groups, an ADC value equal to or less than the optimal cutoff remained a significant predictor of recurrence (odds ratio 6.3, 95% CI 1.23-32.2, p=0.027).
CONCLUSION: Pretreatment ADC values may be an independent predictor of bladder cancer recurrence.
Written by:
Funatsu H, Imamura A, Takano H, Ueda T, Uno T. Are you the author?
Division of Diagnostic Imaging, Chiba Cancer Center, 666-2 Nitona-cho, Chuo-ku, Chiba 260-8717, Japan.
Reference: Eur J Radiol. 2012 Jul 19. Epub ahead of print.
doi: 10.1016/j.ejrad.2012.06.009
PubMed Abstract
PMID: 22819133
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