Upper Tract Tumors

Long term outcomes of ureteroscopic management of upper tract urothelial carcinoma.

Upper tract urothelial carcinoma (UTUC) is relatively rare. While nephroureterectomy is considered the gold standard for treatment, endoscopic nephron- sparing techniques have emerged for select cases with equivalent cancer specific survival (CSS).

Diagnostic utility of axial imaging in the evaluation of hematuria: A systematic review and critical appraisal of the literature.

Increasing severity of hematuria is instinctively associated with higher likelihood of urological malignancy. However, the robustness of the evidentiary base for this assertion is unclear, particularly as it relates to the likelihood of upper urinary tract pathology.

Modified Glasgow prognostic score is a pre-surgical prognostic marker of disease mortality in upper urinary tract urothelial carcinoma.

To investigate the prognostic value of pre-surgical modified Glasgow prognostic score in upper urinary tract urothelial carcinoma patients treated with radical nephroureterectomy.

We retrospectively reviewed the clinical records of 273 urinary tract urothelial carcinoma patients treated with radical nephroureterectomy.

Expression of Nectin-4 and PD-L1 in Upper Tract Urothelial Carcinoma.

Enfortumab vedotin is a novel antibody-drug conjugate targeting Nectin-4, which is highly expressed in urothelial carcinoma. However, the expression status of Nectin-4 in upper tract urothelial carcinoma (UTUC) remains unclear.

Does Xylinas' nomogram accurately predict intravesical recurrence risk after radical nephroureterectomy for primary upper urinary tract urothelial carcinoma when applied to Asian populations?

To validate a prognostic nomogram (Xylinas' nomogram) for intravesical recurrence after radical nephroureterectomy for primary upper urinary tract urothelial carcinoma patients of Asian descent.

Clinicopathological and survival data from 243 primary urinary tract urothelial carcinoma patients who underwent radical nephroureterectomy with bladder cuff excision between January 2004 and May 2017 were collated.

Management of the Distal Ureter in Radical Laparoscopic Nephroureterectomy for Upper Tract Urothelial Carcinoma.

Introduction: Management of the distal ureter during laparoscopic nephroureterectomy (LNU) for upper tract urothelial carcinoma (UTUC) is controversial.

Preintervention risk stratification of renal pelvic cancer and ureteral cancer should differ.

To identify different preintervention prognostic factors between renal pelvic cancer (RPc) and ureteral cancer (Uc) and to develop different preintervention risk stratifications for each cancer type.

Arsenic Exposure Is Associated with Significant Upper Tract Urothelial Carcinoma Health Care Needs and Elevated Mortality Rates - Beyond the Abstract

Arsenic exposure in Northern Chile: Antofagasta is located in the Atacama Desert, one of the aridest regions worldwide. Sources of water for consumption are scarce and originate from underground aquifers, leaching arsenic and other minerals as they flow downslope through the Andes Mountains. Until the 1950s, drinking water in the region met criteria considered acceptable for those times. However, in 1958, the waters of the Toconce river were captured using a 300 km piping system in order to satisfy the increasing demands of drinking water in this flourishing mining region. The latter caused an abrupt increase in mean arsenic concentrations in drinking water from around 90 to about 900 mg/L, exposing the population to levels up to 17 times higher than those recommended by the World Health Organization (WHO) at that time. Unfortunately, the need to support population and economic growth made the authorities to overlook potential risks related to arsenic exposure. Efforts to reduce arsenic started only over 10 years later. In 1970, a water treatment plant with adequate technology was installed, leading to significant drops in arsenic concentrations. Thereafter, a series of changes incorporating new cleaner sources up in the Andes and the modernization of the water supply network led to sustained reductions on arsenic levels, reaching WHO recommended levels by 1990.

Long-term ureteroscopic management of upper tract urothelial carcinoma: 28-year single-centre experience.

Long-term survival outcomes of patients who undergo endoscopic management of non-invasive upper tract urothelial carcinoma remain uncertain. The longest mean follow-up period in previous studies was 6.

Nephroureterectomy of Right-to-Left Crossed Fused Renal Ectopia with Urothelial Carcinoma.

Urothelial carcinoma in a crossed fused renal ectopia (CFRE) is an exceedingly rare clinical finding. We describe the surgical management used to treat upper tract urothelial carcinoma in a 64-year-old man with a right-to-left CFRE.

Diagnostic accuracy of ureteroscopic biopsy in predicting stage and grade at final pathology in upper tract urothelial carcinoma: Systematic review and meta-analysis.

To assess the accuracy of ureteroscopic (URS) biopsies in predicting stage and grade at final pathology in upper tract urothelial carcinoma (UTUC).

The meta-analysis was performed in accordance with the PRISMA statement.

Nomograms to predict overall and cancer-specific survival in patients with upper tract urothelial carcinoma: a large population-based study.

To develop and validate survival nomograms for predicting the overall survival (OS) and cancer-specific survival (CSS) in upper tract urothelial carcinoma (UTUC) patients.

Patients diagnosed with UTUC from 2010 to 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were retrospectively enrolled.

Clinicopathological characteristics, prognosis, and chemosensitivity in patients with metastatic upper tract urothelial carcinoma.

To investigate the clinical characteristics, chemosensitivity, and outcome of metastatic upper tract urothelial carcinoma (UTUC).

Records of patients with metastatic UTUC since January 2005 were retrieved from a database that included clinical and survival data.

Intraoperative prophylactic intravesical chemotherapy to reduce bladder recurrence following radical nephroureterectomy.

Single, postoperative instillation of prophylactic intravesical chemotherapy (pIVC) is effective in reducing bladder cancer recurrences following radical nephroureterectomy (RNU). Despite high level evidence, pIVC is underutilized.

The Diagnostic Yield and Concordance of Ureterorenoscopic Biopsies for Grading of Upper Tract Urothelial Carcinoma: A Dutch Nationwide Analysis - Beyond the Abstract

During the last decade, ureterorenoscopic laser ablative treatment of upper tract urothelial carcinoma (UTUC) has gained great popularity. This development is unsurprising in light of the renal sparing character of the ureteroscopic treatment with a similar oncologic outcome in low-grade and non-invasive UTUC as radical nephroureterectomy.1 Yet, accurate patient selection is required to warrant good oncologic results. To aid patient selection, a risk-stratification has been implemented in international guidelines.2-4 This risk-stratification relies on the tumor stage, the cytologic grade, or the histopathologic grade. As such, if radiologic imaging and cytology do not provide diagnostic certainty, ureterorenoscopic biopsies are essential to the diagnostic approach. However, with regard to the limited diagnostic yield and the high rate of upgrading of ureterorenoscopic biopsies,5-8 the current approach towards patient selection might lead to suboptimal oncologic outcomes. To our knowledge, large, nationwide studies to evaluate the above-mentioned diagnostic limitations were lacking.

The implementation and utility of patient screening logs in a multicentre randomised controlled oncology trial.

The utility of patient screening logs and their impact on improving trial recruitment rates are unclear. We conducted a retrospective exploratory analysis of screening data collected within a multicentre randomised controlled trial investigating chemotherapy for upper tract urothelial carcinoma.

Safety and feasibility of early single dose mitomycin-C bladder instillation post robot-assisted radical nephroureterectomy.

To assess the safety and feasibility of early single dose mitomycin-C (MMC) bladder instillation following robot-assisted radical nephroureterectomy (RANU) at a tertiary kidney cancer centre. Radical nephroureterectomy with bladder cuff excision and subsequent mitomycin-C (MMC) bladder instillation to reduce recurrence risk is the gold standard for high risk upper urinary tract urothelial carcinoma (UUTUC).

Incidence of upper tract urothelial carcinoma in Spain.

The incidence of upper urinary tract tumors is currently unknown. The aim of this study is to determine the real incidence of upper tract urothelial carcinoma (UTUC) in Spain.

A descriptive, prospective and multicenter epidemiological study was conducted in 31 Spanish facilities by means of the Platform for Multicenter Studies of the Spanish Association of Urology.

European Association of Urology Guidelines on Upper Urinary Tract Urothelial Carcinoma: 2020 Update.

The European Association of Urology (EAU) Guidelines Panel on Upper Urinary Tract Urothelial Carcinoma (UTUC) has prepared updated guidelines to aid clinicians in the current evidence-based management of UTUC and to incorporate recommendations into clinical practice.

Survival Benefits Based on the Number of Lymph Nodes Removed during Radical Nephroureterectomy for Upper Tract Urothelial Carcinoma: Systematic Review and Meta-Analysis.

The role of lymph node dissection (LND) is still controversial for upper tract urothelial carcinoma (UTUC), and there are no guidelines regarding its use. This study was conducted to find a higher level of evidence for the survival benefits based on the number of LNs removed during radical nephroureterectomy (RNUx) through a systematic review and meta-analysis.