Washington, DC (UroToday.com) Dr. Daniel Moreira and colleagues presented their findings on the association of chronic prostate inflammation and tumor grade at the SUO 2015 poster session. In an analysis of the REDUCE study, the investigators studied 889 men aged 50-75 years old with negative baseline biopsies and positive 2 year repeat biopsies.
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Acute and chronic inflammation was identified in 10% of biopsies, chronic alone in 60%, and acute alone in 1%. Chronic inflammation was associated with larger prostates.
The investigators found that low grade tumors were more common than high grade at 2 year biopsy (70 vs 30%). Acute inflammation was not associated with grade. On multivariate analysis, men with baseline chronic inflammation had significantly lower risk of high grade disease (OR 0.68, CI 0.50-0.93, p=0.016) compared to men without inflammation.
Daniel Moreira, MD.
Nikhil Waingankar, MD. from the Society of Urologic Oncology Meeting - December 2 - 4, 2015 – Washington, DC.
Fox Chase Cancer Center, Philadelphia, PA.