ASCO 2017: Astellas and Seattle Genetics Announce Updated Enfortumab Vedotin Phase 1 Data in Metastatic Urothelial Cancer

Chicago, IL (UroToday.com) Updated phase 1 data for enfortumab vedotin (ASG-22ME) studied as monotherapy treatment for metastatic urothelial cancer (mUC) was highlighted in an oral presentation at the American Society of Clinical Oncology (ASCO) 52nd Annual Meeting in Chicago.

ASCO 2017: The clinical role of purified protein derivative skin test reaction in patients with non-muscle invasive bladder cancer treated with bacillus-Calmette Guerin

Chicago, IL (UroToday.com) Non-muscle invasive bladder cancer (NMIBC) still represents 70% of the patients who present with bladder cancer (BC). High-grade NMIBC represents a particularly troublesome cohort for whom clinical progression to MIBC remains a high risk, but for whom there are not many treatment options.

ASCO 2017: Cabazitaxel in patients with locally advanced or metastatic transitional cell carcinoma who developed disease progression within 12 months of platinum based chemotherapy: Results of a phase II trial—CAB-B1.

Chicago, IL (UroToday.com) In the past 1 year, five different immune checkpoint inhibitors have been approved by the FDA approved for the treatment of metastatic or advanced urothelial carcinoma (UC): atezolizumab, durvalumab, nivolumab, pembrolizumab and most recently avelumab.

ASCO 2017: Effectiveness of the Moreau strain of Bacillus Calmette-Guerin (BCG) for nonmuscle invasive bladder cancer

Chicago, IL (UroToday.com) Non-muscle invasive bladder cancer (NMIBC) still represents 70% of the patients who present with bladder cancer (BC). High-grade NMIBC represents a particularly troublesome cohort for whom clinical progression to MIBC remains a high risk, but for whom there are not many treatment options.

ASCO 2017: Survival outcomes in elderly patients with muscle invasive bladder cancer: An analysis of the National Cancer Database

Chicago, IL (UroToday.com) Muscle-invasive bladder cancer (MIBC) is a disease process for which we have not made much inroads in the past few decades; despite the introduction of neoadjuvant chemotherapy (NAC), the survival for patients with MIBC has remained relatively unchanged.

ASCO 2017: Comprehensive molecular characterization and analysis of muscle-invasive urothelial carcinomas

Chicago, IL (UroToday.com) Dr. Lerner presented a continuation of a study published in 2014 on 131 tumors that had integrated molecular analysis.1  This original publication analyzed 131 tumors of advanced bladder urothelial carcinoma showing 32 significantly mutated genes, 9 not previously reported. This current presentation focused on the follow-up analysis of the entire cohort, composed of 412 tumors from the TCGA project in chemotherapy-naïve, muscle-invasive urothelial bladder cancer. 

ASCO 2017: Epacadostat plus pembrolizumab in patients with advanced urothelial carcinoma: Preliminary phase I/II results of ECHO-202/KEYNOTE-037

Chicago, IL (UroToday.com) Pembrolizumab (Pembro), a PD-1 inhibitor, is active and well tolerated in platinum-treated, advanced urothelial carcinoma (UC) patients. Epacadostat (Epac) potently and selectively inhibits indoleamine 2,3-dioxygenase 1 (IDO1), a tryptophan-catabolizing enzyme that suppresses T-cell–mediated immune surveillance. IDO1 overexpression is associated with tumor progression and shortened patient survival.
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