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If you treat mCRPC you need to know about mismatch repair. I don’t say this often, but it could be a matter of life or death. And that is not an exaggeration.

Ok, now that I have your attention, let’s talk about the science, the clinical care and the implications for the field.

But first, a brief case. Consider my patient Arnold (not his real name). He is a 68-year old man who underwent radical prostatectomy in 2011.
Late last November Bayer issued a press release notification of the premature halting of a study in which abiraterone and prednisone plus radium 223 was being compared to abiraterone and prednisone alone (ERA 223, NCT02043678). The announcement revealed that the study was being terminated early due to an imbalance in fractures and survival between the two arms – favoring the control arm
Brief high-level review of the LATITUDE and STAMPEDE Studies

LATITUDE was a phase III trial of men with high-volume metastatic prostate cancer (PC) that had not been previously treated with androgen deprivation therapy (ADT).1 The patients were randomized to receive standard ADT with placebos vs. ADT plus abiraterone and prednisone. The primary endpoint is overall survival (OS).
One of the biggest misconceptions in all of cancer care and oncology is the notion that a solid tumor ‘recurs’ after local therapy. If, as is often stated, ‘we got it all’ during surgery, then how can a cancer recur? The answer of course is that it was there all along. But that’s only the beginning of the story.
Cancer can limit one’s physical activity. Can physical activity limit one’s cancer? I’ve become a convert to thinking that it is possible that it can. I’m not convinced yet, but a few years ago I decided that it was worth my time and effort to study it. Compelling patient stories stick with us. I’ll never forget the story of a patient of mine who died several years ago. Let’s call him Dan.
Cell Free DNA analysis may improve the scalability of genomics for prostate cancer.  The management of CRPC has long been plagued by the inability of clinicians to get an accurate sense of the underlying biology of the tumor that they are treating. 
The flurry of media recently in reaction to Senator John McCain’s diagnosis of glioblastoma multiforme, a highly malignant brain tumor, touched right at the heart of where cancer fits in the American psyche:  That it is a battle to be won.

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