FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
Capsular leiomyoma of the kidney is a rare benign tumor. Usually they are very small tumors and do not produce symptoms. We report a case of a huge renal capsular leiomyoma in a pregnant woman, which led to premature delivery of the baby.
Tanveer Iqbal Dar, Abdul Rouf Khawaja, Mohd Sajid Bazaz, Farzana Bashir, Ajay Kumar Sharma
Submitted January 15, 2013 - Accepted for Publication February 4, 2013
KEYWORDS: Leiomyoma, kidney, pregnancy
CITATION: UroToday Int J. 2013 April;6(2):art 16. http://dx.doi.org/10.3834/uij.1944-5784.2013.04.03
Leiomyoma of the kidney is a rare benign tumor, usually asymptomatic, and mistaken as malignant. Diagnosis is made only on histopathology. They are usually less than 1 cm in diameter, and large ones are rare. Less than 100 cases of renal leiomyomas are reported in the literature , but to the best of our knowledge, none have been reported with a pregnancy.
A 30-year-old primigravida female was referred to our department 3 days after delivering a premature male baby, with a globular abdominal mass occupying the right hemi abdomen, crossing the midline. She was referred with a computed tomography- (CT) documented huge, lower pole renal tumor, possibly benign (Figure 1). She did not reveal any previous history of an abdominal mass. An intraoperative frozen section revealed features of leiomyoma kidney and, therefore,
lower polar partial nephrectomy was performed. She was discharged on the seventh postoperative day in a stable condition. Histopathology showed a leiomyoma arising from the renal capsule (Figure 2 and Figure 3).
Leiomyomas usually present between the second and fifth decade of life, with a female preponderance (66%) . These tumors are commonly seen in relation to the lower pole of the kidney (74%), with equal incidence in both kidneys. They can develop from the renal areas that normally contain smooth muscles, such as the renal capsule (37%), the renal pelvis (17%), renal cortical vasculature (10%), and indeterminate areas . Their average size is less than 5 mm , they are usually asymptomatic, and when symptomatic they present as a large palpable mass (57%), with pain (53%), and with microscopic hematuria (20%). Diagnosis cannot be established by imaging alone. Small renal capsular leiomyomas typically appear as well circumscribed masses with homogenous enhancement on CT imaging and an occasional cleavage plane between the renal cortex and the tumor . Irregular calcification may be seen in up to 20% of cases [4,5]. In large leiomyomas, the loss of fat planes makes it difficult to differentiate it from leiomyosarcomas, large exophytic renal carcinomas, and angiomyolipomas. Total nephrectomy is indicated for large leiomyomas to avoid the risk of necrosis, infection, and malignant degeneration; however, the exact risk is not known .
Giant leiomyomas of the kidney are rare tumors, which can grow rapidly in pregnancy, leading to premature termination of the pregnancy along with diagnostic difficulties.
- Rao, V. S., R. Naik, et al. (2001). “Leiomyoma of the kidney--report of two cases.” Indian J Pathol Microbiol 44(3): 343-344.
- Steiner, M., D. Quinlan, et al. (1990). “Leiomyoma of the kidney: presentation of 4 new cases and the role of computerized tomography.” J Urol 143(5): 994-998.
- Fishbone, G. and A. J. Davidson (1969). “Leiomyoma of the renal capsule.” Radiology 92(5): 1006-1007.
- Lee, S. Y., H. H. Hsu, et al. (2006). “Renal capsular leiomyoma--imaging features on computed tomography and angiography.” Nephrol Dial Transplant 21(1): 228-229.
PubMed | CrossRef
- Nagar, A. M., A. A. Raut, et al. (2004). “Giant renal capsular leiomyoma: study of two cases.” Br J Radiol 77(923): 957-958.
PubMed | CrossRef