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- Jonathan Coleman joins Sam Chang for a case-based clinical conversation on the management of upper tract urothelial carcinoma (UTUC). Dr. Coleman presents a case of a 71-year-old woman with microhematuria. Her CT scan identified a mass in the right renal pelvis and her cystoscopy was unremarkable. Dr. Coleman talks through the steps that were taken in the management of this case, which involved a...
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- In a comprehensive discussion hosted by Ashish Kamat, Bishoy Faltas delves into the genomics of upper tract urothelial carcinoma (UTUC). Dr. Faltas emphasizes the distinct biological differences between UTUC and bladder urothelial carcinoma (BUC), notably in genomic and transcriptomic features. He discusses the advanced stage at which UTUC often presents and the role of environmental exposures. Ke...
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- Alicia Morgans and Petros Grivas discuss several ongoing or recently launched trials on urothelial carcinoma. Dr. Grivas provides an update on the ECOG-ACRIN 8192 trial for upper tract urothelial carcinoma, which follows the ECOG-ACRIN 8141 trial. The latter set a benchmark for expected pathological complete response rates with standard care chemotherapy for bladder cancer. The upcoming 8192 trial...
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- Seth Lerner, MD, FACS, presents updated information on the United States Federal Drug Administration (FDA) approval of Jelmyto (UGN-101) for low-grade upper tract urothelial carcinoma (LG-UTUC), and the results of the OLYMPUS trial, Optimized DeLivery of Mitomycin for Primary UTUC Study (Olympus) . LG-UTUC is rare and previously there were few kidney-sparing options. UGN-101 is a mixture of a ther...
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- Seth Lerner and Sam Change discuss the recent phase 3 OLYMPUS study, published in The Lancet Oncology. Dr. Lerner was the principal investigator of the single-arm study which investigated the use of thermal-reversible gel mitomycin (Jelmyto) for low-grade upper tract urothelial cancer (UTUC). The study had a 59% complete response rate and thus identified and the FDA approved Jelmyto as a kidney-sp...
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- Vitaly Margulis joins Ashish Kamat in a discussion on the top three developments in upper tract urothelial treatment starting with localized disease and moving onto the more advanced disease. With the difficulty in administering treatment in the upper tract, Dr. Margulis highlights intracavitary therapies, genetic changes that are prevalent in upper tract advanced disease, and the use of systemic...
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- The OLYMPUS trial, which led to the approval of Jelmyto (Mitomycin gel) for low-grade upper tract urothelial cancer (UTUC), is an open-label, single-arm, phase 3 trial that aimed to assess the safety and activity of a non-surgical treatment using instillation of UGN-101, a mitomycin containing reverse thermal gel, a kidney-sparing treatment. In this video interview with Sam Chang, Seth Lerner, the...
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- Ashish Kamat invites Alison Birtle to share a review of a Phase III Randomized Trial of Perioperative Chemotherapy versus Surveillance in Upper Tract Urothelial Carcinoma (UTUC) POUT study. The POUT study sought to answer the basic question, does adjuvant chemotherapy reduce the risk of relapse for upper tract urothelial carcinoma (UTUC) patients who've had a potentially "curative," nephroureterec...
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- Petros Grivas hosts Matthew Galsky, Bishoy Faltas and Andrew Hsieh in a discussion about their research programs and recent findings that drive closer to providing personalized medicine in the treatments in metastatic urothelial carcinoma and upper tract urothelial cancers. Groundbreaking work is discussed in this podcast and the three platform papers that discuss this evidence in more detail are...
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- Cora Sternberg, MD, and Alicia Morgans, MD discuss the SAUL (A Study of Atezolizumab in Locally Advanced or Metastatic Urothelial or Non-Urothelial Carcinoma of the Urinary Tract) trial data which represents the "real world" experience with atezolizumab for the treatment of carcinomas of the urinary tract. The SAUL study enrolled patients that typically would be excluded from clinical trials inclu...
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