mHSPC VL

APCCC 2022: First-Line Therapy for Metastatic Castration-Resistant Prostate Cancer - Evan Yu

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Evan Yu discusses the changing landscape of metastatic hormone-sensitive prostate cancer treatment with Alicia Morgans. Dr. Yu provides an overview of the many important questions and concerns clinicians must address in sequencing treatment for mCRPC patients in light of novel hormone therapy agents and the opportunity for triplet therapy. Biographies: Evan Yu, MD , Professor, Department of Medici...

(AFT19) PRESTO Study Prolonging Biochemical Progression-Free Survival in Biochemically Relapsed Prostate Cancer with Intensification of ADT - Charles Ryan

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In this brief commentary, Charles Ryan highlights the phase 3, open-label PRESTO study, its importance, and its uniqueness being the first phase 3 study in serologic relapse prostate cancer with a positive result. Many of these patients with serologic relapse are destined to experience metastatic disease, castration-resistant prostate cancer, and death from the disease. The PRESTO study or the (AF...

Prolonging PSA Progression-Free Survival with Intensification of ADT, the PRESTO Study (AFT19) - Rahul Aggarwal

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In this conversation, Rahul and Charles Ryan discuss the AFT-19, PRESTO study of androgen annihilation in high-risk biochemically relapsed prostate cancer. PRESTO is looking at a finite duration of treatment for patients with a rising PSA after prior surgery in the biochemically recurrent, hormone-sensitive setting. There were three treatment arms. The standard of care was ADT monotherapy, the exp...

From ADT to Triplet Therapy: Rethinking Treatment Paradigms in Metastatic Hormone Sensitive Prostate Cancer - Matthew Smith & Kim Chi

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Alicia Morgans converses with Matthew Smith and Kim Chi about the application of triplet therapy in metastatic hormone sensitive prostate cancer (mHSPC). Dr. Smith outlines the ARASENS study that tests the impact of adding darolutamide, an AR pathway inhibitor, to the standard treatment of androgen deprivation therapy (ADT) and docetaxel. The data suggest a significant survival advantage with trip...

Treatment of Vulnerable/Frail Patients with mHSPC APCCC 2022 Presentation - Alicia Morgans

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At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC) Hybrid Meeting, Alicia Morgans presents the treatment of vulnerable/frail patients with metastatic hormone sensitive prostate cancer (mHSPC). Biographies: Alicia Morgans, MD, MPH , Genitourinary Medical Oncologist, Medical Director of Survivorship Program at Dana-Farber Cancer Institute, Boston, Massachusetts Related Content: APCCC...

Optimal Treatment for mHSPC from a Health Economics Standpoint APCCC 2022 Presentation - Caroline Clarke

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At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC) Hybrid Meeting, Caroline Clarke presents on health economics in metastatic hormone sensitive prostate cancer (mHSPC). Biographies: Caroline S. Clarke, PhD, MSci, BA (Hons), Senior Research Associate in Health Economics, University College London, London, UK Related Content: APCCC 2022: Optimal Treatment for mHSPC from a Health Econo...

Can Biology Help Inform Treatment Decisions In the Management of mHSPC? APCCC 2022 Presentation - Gert Attard

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At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC) Hybrid Meeting, Gert Attard presents on whether we need more granularity in mHSPC, and whether biology can help with treatment decisions. Biographies: Gert Attard, MD, PhD, FRCP, John Black Charitable Foundation Endowed Chair in Urological Cancer Research, University College London Cancer Institute, London, UK Related Content: APCCC...

Advancing Treatment for Metastatic Hormone-Sensitive Prostate Cancer: Insights from ARASENS Trial - Jan Philipp Radtke

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Professor Jan Philipp Radtke joins Alicia Morgans, highlighting his EAU 2022 presentation focused on the ARASENS trial and the efficacy of darolutamide in metastatic hormone-sensitive prostate cancer. The trial's primary endpoint was overall survival, and the addition of darolutamide to standard care showed a significant benefit with a hazard ratio of 0.68. The combination increased the four-year...

Treatment De-escalation Strategies in mHSPC APCCC 2022 Presentation - Bertrand Tombal

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At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC) Hybrid Meeting, Bertrand Tombal presents de-escalation strategies in the management of metastatic hormone-sensitive prostate cancer (mHSPC) Biographies: Bertrand Tombal, MD, PhD, Chairman of the Department of Surgery and Professor of Urology at the Université catholique de Louvain (UCL), Cliniques universitaires Saint-Luc, Brussels,...

Treatment Intensification Strategies in mHSPC: Triplets and More APCCC 2022 Presentation - Christopher Sweeney

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At the 2022 Advanced Prostate Cancer Consensus Conference (APCCC) Hybrid Meeting, Christopher Sweeney presents treatment intensification strategies in metastatic hormone-sensitive prostate cancer (mHSPC), focusing on triplet therapies. Biographies: Christopher Sweeney, MBBS, Professor of Medicine, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA Related Content: APCCC 2022: Treatme...