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5 for 5 Hot Topics: Effect of DRE on the 4Kscore for Aggressive prostate cancer with Michael Maccini.

Michael Maccini, MD. presenting the "Effect of DRE on the 4Kscore for Aggressive Prostate Cancer"  for E. David Crawford's 5 for 5.  

The 4Kscore is a new test using total PSA, free PSA, intact PSA, and human kallikrein 2 (hk2) combined with age, digital rectal exam (DRE) findings, and prior biopsy status to more accurately predict risk of Gleason score ≥7 on prostate biopsy.  Prior studies examining effect of DRE on PSA demonstrated mixed results, but most showed no clinically significant increase in PSA after DRE.  This is the first data being presented examining effect of DRE on 4Kscore results.