Margin Articles

In prostate cancer external beam radiation therapy (EBRT), intra-fraction prostate drifts may compromise the treatment efficacy by underdosing the target and/or overdosing the organs at risk. In this study, a recently developed real-time adaptive planning strategy for intensity-modulated radiation therapy (IMRT) for prostate cancer was evaluated in hypofractionated regimes against traditional treatment planning based on a treatment volume margin expansion.

To evaluate the viability of glomeruli in the peritumor parenchyma of partial nephrectomy (PN) specimens removed for renal cell carcinoma (RCC) and relate it to kidney function, in order to better understand the contribution of peritumor parenchyma to renal function.

Current contouring guidelines for curative radiation therapy for muscle-invasive bladder cancer (MIBC) recommend margins of 1.5-2.0 cm, applied to the clinical target volume (CTV). This study assessed whether the use of volumetric modulated arc therapy (VMAT), cone beam computed tomography (CBCT) and strict bladder preparation allowed for a reduced planning target volume (PTV) expansion, resulting in lower doses to surrounding organs at risk (OARs).

To evaluate the risk factors associated with positive surgical margins' (PSMs) location and their impact on disease-specific survival (DSS) in patients with bladder cancer (BCa) undergoing radical cystectomy (RC).

External beam radiotherapy is a safe and effective curative treatment modality for men with localized prostate cancer (PCa). While traditionally entailing long courses with low daily doses, an appreciation of prostate radiobiology and advancements in radiation delivery have allowed for more abbreviated courses of EBRT.

PURPOSE - To assess the risk factors of positive surgical margins (PSM) and the influence of margin status on recurrence in pT1 clear cell renal cell carcinoma (RCC) following partial nephrectomy (PN).

MATERIALS AND METHODS - Patients (1,831) with pathologically confirmed stage T1 clear cell RCC were retrospectively analyzed following PN at eight institutions in Korea between 1999 and 2011.