Genomic Instability Articles


  • Associations between circulating carotenoids, genomic instability and the risk of high-grade prostate cancer.

    BACKGROUND - Carotenoids are a class of nutrients with antioxidant properties that have been purported to protect against cancer. However, the reported associations between carotenoids and prostate cancer have been heterogeneous and lacking data on interactions with nucleotide sequence variations and genomic biomarkers.

    Published November 23, 2015
  • DNA Repair Pathway Alterations in Bladder Cancer.

    Most bladder tumors have complex genomes characterized by a high mutation burden as well as frequent copy number alterations and chromosomal rearrangements. Alterations in DNA repair pathways-including the double-strand break (DSB) and nucleotide excision repair (NER) pathways-are present in bladder tumors and may contribute to genomic instability and drive the tumor phenotype.

    Published May 2, 2017
  • The Role of Epigenomics in the Study of Cancer Biomarkers and in the Development of Diagnostic Tools.

    Epigenetics plays a key role in cancer development. Genetics alone cannot explain sporadic cancer and cancer development in individuals with no family history or a weak family history of cancer. Epigenetics provides a mechanism to explain the development of cancer in such situations.

    Published November 13, 2015