Cannabinoid Receptor Articles


  • Cannabinoid System Contribution to Control Micturition


    Cannabinoid compounds, such as those that can be extracted from the Cannabis sativa plant (marijuana), produce a very wide array of central and peripheral effects, some of which may be of importance for the control of lower urinary tract function. Thus, stimulation of cannabinoid receptors, located both in the central nervous system and in different components of the lower urinary tract, has been shown to affect both normal micturition and various disturbances of bladder function. It is clear that systemically administered cannabinoids may be able to become clinically useful; however, a much greater understanding of the mechanisms of cannabinoid receptors in the control of the human lower urinary tract is necessary to facilitate development of novel cannabinoid drugs for the treatment of micturition disorders such as overactive bladder syndrome.

    Lysanne Campeau

    Division of Urology, McGill University, Montreal, Quebec, Canada

    Submitted September 1, 2013 - Accepted for Publication September 23, 2013

    KEYWORDS: Cannabinoid, cannabinoid receptor, endocannabinoid, knockout mice, cystometry, bladder, urodynamics

    CORRESPONDENCE: Lysanne Campeau, CM, MD, PhD, FRCSC, Assistant Professor, Division of Urology, Department of Surgery, Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, Quebec, Canada

    CITATION: UroToday Int J. 2013 October;6(5):art 59.

    Published October 27, 2013
  • Simultaneous Activation of Induced Heterodimerization between CXCR4 Chemokine Receptor and Cannabinoid Receptor 2 (CB2) Reveal a Mechanism for Regulation of Tumor Progression.

    The G-protein-coupled chemokine receptor, CXCR4, generates signals that lead to cell migration, cell proliferation, and other survival mechanisms which result in the metastatic spread of primary tumor cells to distal organs.

    Published February 11, 2016