Readressing the rationale of irradiation in Stage I seminoma guidelines: A critical essay.

Germ cell tumors (GCT), accounting for 95% of malignant testicular tumors, can be divided into two groups: seminoma (SGCT) and non-seminoma (NSGCT). Seminomas typically arise in men in the fourth decade of life, compromising 60% of the GCT. At diagnosis, approximately 75% present with local disease (Stage I); 15% is detected with metastatic regional lymph nodes (Stage II) and 5-10% present with juxtaregional or visceral metastasis (Stage III) . This article is protected by copyright. All rights reserved.

BJU international. 2019 Jan 25 [Epub ahead of print]

Maarten Albersen, Charlien Berghen, Pierre Blanchard, Alberto Bossi, Alberto Briganti, Cesare Cozzarini, Karel Decaestecker, Gert De Meerleer, Valérie Fonteyne, Karin Haustermans, Steven Joniau, Daryl Lim Joon, Vincent Khoo, Paul L Nguyen, Piet Ost, Geert Villeirs, Christof Vulsteke, Anthony Zietman

Department of Urology, Leuven University Hospital, Leuven, Belgium., Department of Radiation Oncology, Leuven University Hospital, Leuven, Belgium., Department of Radiation Oncology, Gustave Roussy Cancer Campus, Villejuif, France., Department of Urology, San Raffaele Hospital, Milan, Italy., Department of Radiation Oncology, San Raffaele Hospital, Milan, Italy., Department of Urology, Ghent University Hospital, Ghent, Belgium., Department of Radiation Oncology, Ghent University Hospital, Ghent, Belgium., Olivia Newton John Cancer Centre, Melbourne, Australia., Royal Marsden NHS Foundation Trust, London, United Kingdom., Department of Radiation Oncology, Dana-Farber Cancer Institute, Bringham., Department of Radiology, Ghent University Hospital, Ghent, Belgium., Department of Oncology, Ghent Maria Middelares Hospital., Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts, United States of America.