Some studies have suggested that tubulocystic carcinoma may be related to papillary renal cell carcinoma. We sought to compare and contrast the molecular and immunohistochemical profiles of tubulocystic carcinoma to those of papillary renal cell carcinoma.
Twelve cases of pure tubulocystic renal cell carcinoma were subjected to fluorescence in situ hybridization assessment of chromosomal number for chromosomes 7 and 17, and for TFE3 translocation. Immunohistochemical labeling for AMACR, p63, cytokeratin 7, PAX 8, cytokeratin 20, and carbonic anhydrase IX was assessed in all tumors. No tumor exhibited gains of chromosomes 7 or 17, or TFE3 translocation by fluorescence in situ hybridization. Immunohistochemistry revealed all tumors to be nonreactive with antibodies to p63 and cytokeratin 20. Conversely, the antibody to AMACR gave a positive reaction in the neoplastic cells of all tumors. Four cases demonstrated focal labeling with antibody to carbonic anhydrase IX and 5 tumors showed focally positive reactions with antibody to cytokeratin 7. Recurrence and metastatic disease was not found for the patients with available follow up information.
Pure tubulocystic renal cell carcinoma is an indolent tumor with a good prognosis. Our data support the distinction of this neoplasm as a separate entity. This article is protected by copyright. All rights reserved.
Histopathology 2015 Aug 27 [Epub ahead of print]
Thu Tran, Carol L Jones, Sean R Williamson, John N Eble, David J Grignon, Shaobo Zhang, Mingsheng Wang, Lee Ann Baldridge, Lisha Wang, Rodolfo Montironi, Marina Scarpelli, Puay-Hoon Tan, Novae B Simper, Eva Comperat, Liang Cheng
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN , Department of Pathology, University of Oklahoma College of Medicine, Oklahoma City, OK , Department of Pathology, Henry Ford Hospital, Detroit, MI , Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN , Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN , Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN , Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN , Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN , Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China , Institute of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region (Ancona), United Hospitals, Ancona, Italy , Institute of Pathological Anatomy and Histopathology, School of Medicine, Polytechnic University of the Marche Region (Ancona), United Hospitals, Ancona, Italy , Singapore General Hospital, Singapore , Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN , Department Groupe Hospitalier Pitié-Salpêtrière, Paris, France , Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN