The incidence of patients with multiple primary tumors has been growing in recent years.
The association between Non-Hodgkin's Lymphomas (NHL) and Renal Cell Carcinoma (RCC) is unclear. The presentation of 10 patients with co-existent NHL and RCC at our institution in the past three years led us to explore whether this was a chance association or a statistically significant phenomenon. We used the U.S. Surveillance, Epidemiology, and End Result (SEER) program ( www.seer.cancer.gov ) from 1973 to 2006 to identify a total of 892,445,537 subjects aged 18-84, with known values for race and gender at risk for NHL and RCC. Among these, 181,009 were diagnosed with NHL, 118,122 were diagnosed with RCC, and 1,039 had both NHL and RCC. This was significantly higher than the expected number of 24 with co-existent NHL and RCC (p< 0.0001). The observed number (O) of RCC after NHL was significantly higher than the expected number (E) (O/E: 1.51; 95% CI: 1.36-1.66) with the O/E ratio remaining elevated across the various follow-up time intervals. The observed number of NHL after RCC was not significantly different from the expected number (O/E: 1.09; 95% CI: 0.98-1.22). In univariate analyses, race and gender were significantly associated with an increased cumulative incidence of RCC after NHL. Multivariate analysis with age, race and gender revealed that white males had a higher cumulative incidence of RCC after NHL. These findings suggest that NHL patients are at increased risk for RCC.
Lossos C, Ferrell A, Duncan R, Lossos IS. Are you the author?
Reference: Leuk Lymphoma. 2011 Jul 8. Epub ahead of print.