In Mexico, about 30% of renal cancer patients are diagnosed in a metastatic state. Despite the recent advances in the treatment of cancer, metastatic renal cancer is still an incurable illness. Thus, identifying prognostic factors helps improve prognosis accuracy and survival prediction for patients.
In this study, we retrospectively analyzed 26 patients with histological diagnosis of renal cell carcinoma, including clear cell and other subtypes in stage IV (metastatic), recurrent or unresectable disease. We performed a multivariate analysis of overall survival regarding the congruity between prognostic scales.
Our results showed a significant difference in favor of patients with congruity between scales for progression-free survival (18.9 vs. 3.1 months; P = 0.048) and a tendency towards better overall survival in patients with the congruity of both scales compared to the discordant patients (112 vs. 32 months; P = 0.99).
This study highlights the discordance between Memorial Sloan-Kettering Cancer Center and International Metastatic Renal Cell Carcinoma Database Consortium scales, which was associated with worse prognosis with a significant difference in progression-free survival but not in overall survival.
World journal of oncology. 2022 Apr 23 [Epub]
Hiram Josue Grimaldo-Roque, Erika Adriana Martinez-Castaneda, Mariana G Morales-Garcia, Jorge Luis Leal-Hidalgo, Valeria M Torres-Guillen, Rita Dorantes-Heredia, Daniel Motola-Kuba, Jose Manuel Ruiz-Morales
Medical Oncology Research Unit, Medica Sur Hospital and Clinical Foundation, Mexico City, Mexico., Universidad de las Americas Puebla, San Andres Cholula, Puebla, Mexico., Anatomic Pathology Research Unit, Medica Sur Hospital and Clinical Foundation, Mexico City, Mexico.