Two sporadic cases of eosinophilic solid and cystic renal cell carcinoma (ESC RCC), at our institution, are presented in this study to contribute to the growing literature on this novel renal neoplasm. The first patient was a 38-year-old female with two synchronous renal masses measuring 3.5 and 1.9 cm on preoperative imaging. The second patient was a 44-year-old female with an incidental renal mass measuring 4 cm. Both patients underwent uncomplicated radical nephrectomies. The 1.9 cm mass in the first patient was consistent with clear cell RCC. The dominant mass in the first patient and the tumor in the second patient had microscopic and macroscopic findings in keeping with ESC RCC including a tan appearance, abundant eosinophilic cytoplasm, and CK20+ and CK7- staining. Both patients had an uncomplicated course following surgery with no evidence of local recurrence or distant metastatic disease for 1 and 2 years for the first and second patient accordingly. These cases contribute to a growing body of literature regarding ESC RCC including, to our knowledge, the first reported case of synchronous ESC RCC and clear cell RCC. Further research about this novel renal neoplasm is needed.
International journal of surgical pathology. 2021 Feb 22 [Epub ahead of print]
Seyed Mohammad Mohaghegh Poor, Shivani Mathur, Karl Kassier, Janetta Rossouw, Robert Wightman, Jeff Saranchuk, Ian W Gibson
12359Division of Urology, Department of Surgery, University of Manitoba College of Medicine, Winnipeg, Manitoba, Canada., 1915Brandon Regional Health Centre, Brandon, Manitoba, Canada., Westman Laboratory, 1915Brandon Regional Health Centre, Brandon, Manitoba, Canada., Department of Pathology, 8664University of Manitoba College of Medicine, Winnipeg, Manitoba, Canada.