Precision medicine is beginning to make an impact on the treatment of different diseases, but there are still challenges that must be overcome, such as the complexity of interventions, the need for marker validation, and the level of evidence necessary to demonstrate effectiveness. In this Perspective, we describe how evidence landscapes can help to address these challenges.
Science translational medicine. 2020 Apr 22 [Epub]
Spencer Phillips Hey, Cory V Gerlach, Garrett Dunlap, Vinay Prasad, Aaron S Kesselheim
Harvard Center for Bioethics, Harvard Medical School, Boston, MA, USA. ., Harvard Program in Therapeutic Sciences, Harvard Medical School, Boston, MA, USA., Division of Hematology and Medical Oncology, Knight Cancer Institute, Department of Preventive Medicine and Public Health, and Center for Health Care Ethics, Oregon Health and Science University, Portland, OR, USA., Harvard Center for Bioethics, Harvard Medical School, Boston, MA, USA.