Programmed death-1 receptor (PD-1) and programmed death-1 receptor-ligand (PD-L1) have been suggested to play a role as prognostic markers in clear cell renal cell carcinoma (ccRCC). The association between PD-L1 and prognosis seems to be more robust than for PD-1. Further, preliminary analyses suggest that neither PD-1 nor its ligands play a role as prognostic markers in non-clear cell RCC, while the prognostic role of PD-L2 in ccRCC as well as in non-clear cell RCC remains unclear.
Medical oncology (Northwood, London, England). 2017 Apr 21 [Epub]
Franziska Erlmeier, Wilko Weichert, Andres Jan Schrader, Michael Autenrieth, Arndt Hartmann, Sandra Steffens, Philipp Ivanyi
Institute for Pathology and Pathological Anatomy, Technische Universität München, Trogerstraße 18, 81675, Munich, Germany. ., Institute for Pathology and Pathological Anatomy, Technische Universität München, Trogerstraße 18, 81675, Munich, Germany., Member of the German Renal Cell Tumor Consortium, Jena, Germany., Department of Urology, Technical University of Munich, Klinikum rechts der Isar, Munich, Germany., Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation, Hannover Medical School, Hannover, Germany.