Increased Prostate Specific Membrane Antigen expression promotes tumor progression in prostate epithelium by dysregulating the β1-integrin/type I insulin-like growth factor receptor axis, resulting in a shift in signaling from the less aggressive mitogen-activated protein kinase-extracellular signal-regulated kinases 1 and 2 pathway to the pro-survival protein kinase B(AKT)/phosphatidylinositol 3-kinase pathway.
Molecular & cellular oncology. 2017 Apr 28*** epublish ***
Leslie Ann Caromile, Linda H Shapiro
Center for Vascular Biology, University of Connecticut Health Center, Farmington, CT, USA.