The study sought to prospectively evaluate which technique among T2-weighted images, dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI), diffusion-weighted (DW) MRI, or a combination of the 2, is best suited for prostate cancer detection and local staging.
Twenty-seven consecutive patients with biopsy-proven adenocarcinoma of the prostate underwent MRI on a 1.5T scanner with a surface phased-array coil prior radical prostatectomy. Combined anatomical and functional imaging was performed with the use of T2-weighted sequences, DCE MRI, and DW MRI. We compared the imaging results with whole mount histopathology.
For the multiparametric approach, significantly higher sensitivity values, that is, 53% (95% confidence interval [CI]: 41.0-64.1) were obtained as compared with each modality alone or any combination of the 3 modalities (P < .05). The specificity for this multiparametric approach, being 90.3% (95% CI: 86.3-93.3) was not significantly higher (P < .05) as compared with the values of the combination of T2+DCE MRI, DW+DCE MRI, or DCE MRI alone. Among the 3 techniques, DCE had the best performance for tumour detection in both the peripheral and the transition zone. High negative predictive value rates (>86%) were obtained for both tumour detection and local staging.
The combination of T2-weighted sequences, DCE MRI, and DW MRI yields higher diagnostic performance for tumour detection and local staging than can any of these techniques alone or even any combination of them.
Canadian Association of Radiologists journal = Journal l'Association canadienne des radiologistes. 2017 Jul 15 [Epub ahead of print]
Dimitra Loggitsi, Anastasios Gyftopoulos, Nikolaos Economopoulos, Aikaterini Apostolaki, Theodoros Kalogeropoulos, Anastasios Thanos, Efthimia Alexopoulou, Nikolaos L Kelekis
Second Department of Radiology, General University Hospital Attikon, Haidari, Athens, Greece., Second Department of Radiology, General University Hospital Attikon, Haidari, Athens, Greece. Electronic address: ., Pathology Department, St Savvas Anticancer and Oncology Hospital, Athens, Greece., Urology Department, St Savvas Anticancer and Oncology Hospital, Athens, Greece.