Cellular identity crisis: antiandrogen resistance by lineage plasticity

A recent publication in Science demonstrates the ability of prostate cancer cells to switch lineages from one that is dependent on androgen signaling to a cell type that is not. Known as lineage plasticity, this phenomenon is driven by the transcription factor SOX2 in RB1 and TP53-deficient prostate cancer. SOX2 is a potential prognostic marker and therapeutic target in castration resistant prostate cancer.

Cancer biology & therapy. 2017 May 05 [Epub ahead of print]

Daniel Tuerff, Tristan Sissung, William D Figg

a Clinical Pharmacology Program; Medical Oncology Branch; CCR; NCI/NIH ; National Cancer Institute ; Bethesda , MD USA.

E-Newsletters

Newsletter subscription

Free Daily and Weekly newsletters offered by content of interest

The fields of GU Oncology and Urology are rapidly advancing. Sign up today for articles, videos, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.

Subscribe