The introduction of widespread prostate-specific antigen screening brought about an increase in the detection of clinically low-risk prostate cancer. Many of these patients are overtreated by radical prostatectomy and radiation. Comparatively, focal therapy for prostate cancer offers the advantage of decreased rates of incontinence and impotence. The 12-core extended sextant transrectal ultrasound-guided needle biopsy is unable to safely identify candidates for focal therapy. Multiparametric-MRI and MRI/Ultrasound fusion-guided biopsy can detect more clinically-significant prostate cancers and aid in accurate detection of higher-grade disease. MRI/US fusion-guided prostate biopsy is recommended as a modality of choice for selection of patients for focal therapy.
Urology. 2017 Feb 23 [Epub ahead of print]
Jennifer Gordetsky, Soroush Rais-Bahrami, Jonathan I Epstein
Department of Pathology, The University of Alabama at Birmingham, Birmingham, Alabama; Department of Urology, The University of Alabama at Birmingham, Birmingham, Alabama. Electronic address: ., Department of Urology, The University of Alabama at Birmingham, Birmingham, Alabama; Department of Radiology, The University of Alabama at Birmingham, Birmingham, Alabama., Department of Pathology, The Johns Hopkins Hospital, Baltimore, Maryland; Department of Urology, The Johns Hopkins Hospital, Baltimore, Maryland.