PSMA-targeted contrast agents for intraoperative imaging of prostate cancer.

Prostate-specific membrane antigen (PSMA) can serve as a molecular cell surface target for the detection and treatment of prostate cancer. Near-infrared (NIR) fluorescence imaging enables highly sensitive, rapid, and non-radioactive imaging of PSMA, though specific targeting still remains a challenge because no optimized contrast agents exist.

Chemical communications (Cambridge, England). 2017 Jan 13 [Epub ahead of print]

Kai Bao, Jeong Heon Lee, Homan Kang, G Kate Park, Georges El Fakhri, Hak Soo Choi

Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA 02114, USA. and Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China., Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, MA 02114, USA. .