Materials and Methods: Cumulative (CTCAE v 4.0) toxicity was evaluated by log-rank test. For quality-of-life (QOL) the Expanded Prostate Cancer Index Composite (EPIC) was utilized and mean changes from baseline in EPIC domains were tested by repeated measures models. Proportions of men with minimally important differences (MID) in each domain were tested using repeated measures logistic models with pre-specified thresholds.
FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
Further, Control men were also more likely to see large declines (twice MID) in bowel (21% vs 5%, p=0.02) and urinary QOL (23% vs. 8%, p=0.02).
Conclusion: The benefit of a hydrogel spacer in reducing rectal dose, toxicity, and QOL declines following IG-IMRT for prostate cancer were maintained or increased with longer follow-up providing stronger evidence for the benefit of hydrogel spacer for prostate radiotherapy.
Hamstra DA, Mariados N, Sylvester J, Shah D, Karsh L, Hudes R, Beyer D, Kurtzman S, Bogart J, Hsi RA, Kos M, Ellis R, Logsdon M, Zimberg S, Forsythe K, Zhang H, Soffen E, Francke P, Mantz C, Rossi P, DeWeese T, Daignault-Newton S, Fischer-Valuck BW, Chundury A, Gay H, Bosch W, Michalski J, Continued Benefit to Rectal Separation for Prostate RT: Final Results of a Phase III Trial, International Journal of Radiation Oncology • Biology • Physics (2017), doi: 10.1016/ j.ijrobp.2016.12.024.
Read Full Text Article - International Journal of Radiation Oncology • Biology • Physics (2017).