Molecular imaging for prostate cancer: Performance analysis of (68)Ga-PSMA PET/CT versus choline PET/CT.

There is a need for a precise and reliable imaging to improve the management of prostate cancer. In recent years the PET/CT with choline has changed the handling of prostate cancer in Europe, and it is commonly used for initial stratification or for the diagnosis of a biochemical recurrence, although it does not lack limitations. Other markers are being tested, including the ligand of prostate-specific membrane antigen (PSMA), that seems to offer encouraging prospects. The goal of this piece of work was to critically review the role of choline and PSMA PET/CT in prostate cancer.

A systematic literature review of databases PUBMED/MEDLINE and EMBASE was conducted searching for articles fully published in English on the PET marker in prostate cancer and its clinical application.

It seems as 68Ga-PSMA PET/CT is better than PET/CT in prostate cancer to detect primary prostate lesions, initial metastases in the lymph nodes and recurrence. However, further research is required to obtain high-level tests. Also, other PET markers are studied. Moreover, the emergence of a new PET/MR camera could change the performance of PET imaging.

Actas urologicas espanolas. 2016 Jan 29 [Epub ahead of print]

L Michaud, K A Touijer

Departamento de Cirugía, Memorial Sloan Kettering Cancer Center, New York, NY, Estados Unidos; Servicio de Diagnóstico y Terapia por imagen, Memorial Sloan Kettering Cancer Center, New York, NY, Estados Unidos., Servicio de Urología, Departamento de Cirugía, Memorial Sloan Kettering Cancer Center, New York, NY, Estados Unidos; Departamento de Urología, Weill Cornell Medical College, New York, NY, Estados Unidos. Electronic address: .