This study was conducted in a large population of Finnish twins with 30 years of follow-up data and linkage to national registries. This unique population allowed us to also examine associations within twin pairs, thereby controlling for potentially confounding genetic and shared early environmental factors. Our co-twin analyses did not detect an association for any of the circadian- or sleep-related factors under study. This may have been a chance finding due to lower power of the discordant twin pair analysis, or it may suggest that the significant association between chronotype and risk in the overall study population was driven by an unaccounted for shared genetic or environmental confounder.
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Written by: Barbra Dickerman
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