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The results of the study showed that APC was less commonly palpable (p<0.001) and needed more frequent repeat biopsy (p=0.012) than posterior prostate cancer. Anterior group also had fewer positive cores than the posterior group (p<0.001), despite comparable tumor volumes. The Gleason score upgrading was more frequently observed in anterior than in posterior prostate cancer (p=0.003). The estimated 5-year biochemical recurrence-free survival in patients with anterior prostate cancer was significantly higher than in patients with posterior prostate cancer (p<0.001).The multivariate analysis also showed that the anterior location was an independent prognostic factor for biochemical recurrence (HR 0.403, p=0.006) along with other well-known prognostic factors. The MRI’s sensitivity and specificity for anterior prostate tumors was 78.1% and 58.2%, respectively.
In conclusion, pathological features are similar in APC and PPC, but anterior prostate cancer has more favorable oncologic outcomes while also more frequent Gleason score upgrading. The use of multiparametric MRI has moderate diagnostic performances for anterior prostate cancers, and should be advised to identify tumor locations and extent for preoperative risk evaluations. The authors acknowledges limitations to the study, including retrospective study, pathological and oncologic characteristics bias, the examiners were not blinded to preoperative evaluations, and interobserver consistency assessment could not be performed.
Authors: Myong Kim, Seung-Kwon Choi, Myungchan Park, Myungsun Shim, Cheryn Song, In Gab Jeong, Jun Hyuk Hong, Choung-Soo Kim and Hanjong Ahn
Affiliations: Department of Urology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea
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Terris MK, Freiha FS, McNeal JE et al: Efficacy of transrectal ultrasound for identification of clinically undetected prostate cancer. J Urol1991; 146: 78.
Bott SRJ, Young MPA, Kellett MJ et al: Contributors to the U. C. L. Hospitals’ Trust Radical Prostatectomy Database. Anterior prostate cancer: is it more difficult to diagnose? BJU Int 2002; 89: 886.
Koppie TM, Bianco FJ, Kuroiwa K et al: The clinical features of anterior prostate cancers. BJU Int 2006; 98: 1167.
Heidenreich A, Bastian PJ, Bellmunt J et al: EAU guidelines on prostate cancer. Part 1: screening, diagnosis, and local treatment with curative intent-update 2013. Eur Urol 2014; 65: 124.
Mohler JL, Kantoff PW, Armstrong AJ et al: Prostate cancer, version 2.2014. J Natl Compr Canc Netw 2014; 12: 686.
Thompson I, Thrasher JB, Aus G et al: Guideline for the management of clinically localized prostate cancer: 2007 update. J Urol 2007; 177: 2106.