Length of capsular contact on prostate MRI as a predictor of extracapsular extension: which is the most optimal sequence?

Length of capsular contact (LCC) is a promising biomarker for predicting extracapsular extension (ECE), but the most optimal magnetic resonance imaging (MRI) sequence for measuring LCC is yet to be determined.

To evaluate LCC using different MRI sequences for determining ECE in prostate cancer.

A total of 185 patients underwent prostate MRI followed by radical prostatectomy. LCC was measured separately on T2-weighted (T2W) images, apparent diffusion coefficient (ADC) maps, and dynamic contrast-enhanced (DCE) MRI. LCCs (LCCT2, LCCADC, LCCDCE, and LCCmax [greatest value of 3 LCCs]) were compared between sequences using Wilcoxon signed rank test and was tested for determining ECE using the Mann-Whitney U test, ROC curve analysis, and logistic regression analysis.

There were no significant differences among LCCs (P = 0.333-0.837). All LCCs were significantly greater in patients with ECE (P < 0.001). The optimal threshold value for predicting ECE was >14, >13, >12, and >14 mm for LCCT2, LCCADC, LCCDCE, and LCCmax, respectively. LCCmax yielded the highest area under the curve (0.895) which was significantly greater than that by LCCADC (0.858, P = 0.030). Otherwise, there were no significant difference between LCCs (P = 0.052-0.985). At univariate analysis, age, clinical stage, PSA, Gleason score, and all LCCs were significantly associated with ECE (P < 0.001-0.040). At multivariate analysis, GS (P ≤ 0.008) and all LCCs (P < 0.001) were independently predictive factors.

LCC measured on any sequence was significantly different in patients with and without ECE and was independently associated with the presence of ECE. Although LCCmax showed the greatest ability to predict ECE, there was relatively equivalent performance among different MRI sequences.

Acta radiologica (Stockholm, Sweden : 1987). 2016 Jul 20 [Epub ahead of print]

Sungmin Woo, Sang Youn Kim, Jeong Yeon Cho, Seung Hyup Kim

Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea., Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea ., Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea Institute of Radiation Medicine and Kidney Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea., Department of Radiology, Seoul National University Hospital, Seoul, Republic of Korea Institute of Radiation Medicine and Kidney Research Institute, Seoul National University Medical Research Center, Seoul, Republic of Korea.

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