Prostate cancer and the unfolded protein response

The endoplasmic reticulum (ER) is an essential organelle that contributes to several key cellular functions, including lipogenesis, gluconeogenesis, calcium storage, and organelle biogenesis. The ER also serves as the major site for protein folding and trafficking, especially in specialized secretory cells. Accumulation of misfolded proteins and failure of ER adaptive capacity activates the unfolded protein response (UPR) which has been implicated in several chronic diseases, including cancer. A number of recent studies have implicated UPR in prostate cancer (PCa) and greatly expanded our understanding of this key stress signaling pathway and its regulation in PCa. Here we summarize these developments and discuss their potential therapeutic implications.

Oncotarget. 2016 Jun 09 [Epub ahead of print]

Margrethe Storm, Xia Sheng, Yke Jildouw Arnoldussen, Fahri Saatcioglu

Department of Biosciences, University of Oslo, Oslo, Norway., Department of Biosciences, University of Oslo, Oslo, Norway., Department of Biological and Chemical Work Environment, National Institute of Occupational Health, Oslo, Norway., Department of Biosciences, University of Oslo, Oslo, Norway.

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