Prostate cancer (PCa) is the most common malignancy in males worldwide. Approximately 30% of those patients who received radical prostatectomy developed clinical recurrence accompanied by elevated serum prostate‑specific antigen levels.
FREE DAILY AND WEEKLY NEWSLETTERS OFFERED BY CONTENT OF INTEREST
Did you find this article relevant? Subscribe to UroToday-GUOncToday!
The fields of GU Oncology and Urology are advancing rapidly including new treatments, enrolling clinical trials, screening and surveillance recommendations along with updated guidelines. Join us as one of our subscribers who rely on UroToday as their must-read source for the latest news and data on drugs. Sign up today for blogs, video conversations, conference highlights and abstracts from peer-review publications by disease and condition delivered to your inbox and read on the go.
Although knowledge regarding the development of PCa has been significantly improved, the molecular mechanism underlying recurrence remains largely unknown. The objective of the present study was to identify the differentially expressed microRNAs (miRNAs) in recurrent PCa to explore the possible involvement of miRNAs in the relapse. The expression of 6 miRs that have been previously reported to be downregulated in PCa stem cells were examined in a total of 32 recurrent and 36 non‑recurrent PCa samples, and let‑7a was substantially decreased in the recurrent PCa. Using the online prediction tools, let‑7a was identified to virtually target insulin‑like growth factor 1 receptor (IGF1R). IGF1R as a target of let‑7a was subsequently validated using the luciferase assay. Exogenous expression of let‑7a suppressed the expression of IGF1R, and reduced the proliferation of PCa cells by introducing apoptosis to the cells. In conclusion, the present data demonstrated a possible involvement of let‑7a in the pathogenesis of recurrent PCa, and it may be a potential target of the disease.
International journal of molecular medicine. 2015 Sep 29 [Epub ahead of print]
Bing Tian, Nannan Huo, Meng Li, Yong Li, Zhongzhou He
Department of Urology, Affiliated Xinhua Hospital of Dalian Medical University, P. R. China. , Department of Urology, Affiliated Xinhua Hospital of Dalian Medical University, P. R. China. , Department of Urology, Affiliated Xinhua Hospital of Dalian Medical University, P. R. China. , Department of Urology, Affiliated Xinhua Hospital of Dalian Medical University, P. R. China. , Department of Urology, The First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning 116001, P. R. China.