Seed migration after transperineal interstitial prostate brachytherapy by using loose seeds: Japanese prostate cancer outcome study of permanent iodine-125 seed implantation (J-POPS) multi-institutional cohort study.

BACKGROUND - The incidence and associated factors of loose seed migration were investigated in cohort 1 of the Japanese Prostate Cancer Outcome Study of Permanent Iodine-125 Seed Implantation (J-POPS).

METHODS - The study subjects were 2160 patients, consisting of 1641 patients who underwent permanent iodine-125 seed implantation (PI) and 519 patients who underwent PI combined with external beam radiation therapy (PI + EBRT).

The presence or absence of seed migration to the chest and abdominal/pelvic region was determined.

RESULTS - Seed migration was observed in 22. 7 % of PI group patients and 18. 1 % of PI + EBRT group patients (p = 0. 0276). Migration to the lungs and abdominal/pelvic region was observed in 14. 6 % and 11. 1 % of the patients in the PI group, and 11. 2 % and 8. 5 % of the patients in the PI + EBRT group, respectively. In the PI group, the number of implanted seeds was associated with the seed migration incidence. Neither the PI nor the PI + EBRT group showed any difference in the volume of the prostate receiving 100 % of the prescribed dose (V100 [%]) or the minimal dose received by 90 % of the prostate volume (D90 [Gy]) between the patients with and without seed migration.

CONCLUSIONS - This prospective cohort study investigating the largest number of past cases showed no difference in D90 (Gy) or V100 (%) between seed migration or the absence thereof in both the PI group and PI + EBRT group.

ClinicalTrials. gov: NCT00534196.

Radiation oncology (London, England). 2015 Nov 14*** epublish ***

Masahiro Nakano, Atsunori Yorozu, Shiro Saito, Akitomo Sugawara, Shinichiroh Maruo, Shinsuke Kojima, Takashi Kikuchi, Masanori Fukushima, Takushi Dokiya, Hidetoshi Yamanaka

Department of Urology, Gifu University Graduate School of Medicine, 1-1Yanagito, Gifu-shi, Gifu, 501-1194, Japan. Department of Radiation Oncology, National Hospital Organization, Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan. Department of Urology, National Hospital Organization Tokyo Medical Center, 2-5-1 Higashigaoka, Meguro-ku, Tokyo, 152-8902, Japan. Department of Radiation Oncology, Tokai University, Hachioji Hospital, 1838 Ishikawa-machi, Hachioji-shi, Tokyo, 192-0032, Japan. Translational Research Informatics center, 1-5-4 Minatojima-minamimachi Chuo-ku, Kobe, Hyogo, 650-0047, Japan. Translational Research Informatics center, 1-5-4 Minatojima-minamimachi Chuo-ku, Kobe, Hyogo, 650-0047, Japan. Translational Research Informatics center, 1-5-4 Minatojima-minamimachi Chuo-ku, Kobe, Hyogo, 650-0047, Japan. Translational Research Informatics center, 1-5-4 Minatojima-minamimachi Chuo-ku, Kobe, Hyogo, 650-0047, Japan. Department of Radiology, Kyoundo Hospital, 1-8 Kandasurugadai, Chiyoda-ku, Tokyo, 101-0062, Japan. Institute of Preventive Medicine, Kurosawa Hospital, 187 Yanakamachi, Takasaki-shi, Gunma, 370-1203, Japan.

PubMed