Cytokine-mediated immune and inflammatory responses are considered to play an important role in the pathogenesis of prostate cancer. The present study investigated certain interleukin-1β (IL1β) polymorphisms and their association with prostate cancer.
Genotyping of the IL1B-31(rs 1143627 G>A) and IL1B-511(rs 16944 A<G) polymorphisms were performed using real-time polymerase chain reaction for blood samples from a group of patients with prostate cancer (n=71) and controls (n=76).
The frequency of the IL1B-31(rs1143627) AG heterozygote genotype was found to be significantly lower in patients compared to controls (odds ratio=0. 648, 95% confidence interval=0. 463-0. 908; p=0. 036). The genotypic frequencies of IL1B-511(rs16944) between prostate cancer patients and controls were statistically significantly different (p=0. 001). The frequency of AG genotype for IL1B-511(rs16944) was 0. 5-fold lower in patients with prostate cancer than in the controls (odds ratio=0. 546; 95% confidence interval=0. 377-0. 791; p=0. 001).
Our data show that individuals carrying the IL1B-31(rs1143627) and IL1B-511(rs16944) AG genotypes had a decreased risk for developing prostate cancer. Out of all the possible combinations analyzed, IL1B-31(rs1143627) G with IL1B-511(rs16944) G combination had a protective association with prostate cancer.
Anticancer research. 2015 Nov [Epub]
Faruk Yencilek, Asif Yildirim, Seda Gulec Yilmaz, Emre Murat Altinkilic, Altay Burak Dalan, Yavuz Bastug, Turgay Isbir
Department of Urology Faculty of Medicine. , Department of Urology, Göztepe Education and Research Hospital, Istanbul, Turkey. , Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey. , Department of Molecular Medicine, Institute of Health Sciences, Yeditepe University, Istanbul, Turkey. , Yeditepe University Hospital, Istanbul, Turkey. , Department of Urology, Fatih Sultan Mehmet Education and Research Hospital, Istanbul, Turkey. , Department of Medical Biology, Faculty of Medicine.